乳果糖对腹腔镜胆囊切除术后肠黏膜屏障及胃肠动力状态的影响研究(1)
【摘要】 目的：研究乳果糖對腹腔镜胆囊切除术后肠黏膜屏障及胃肠动力状态的影响。方法：选取2017年9月-2019年3月本院收治的150例腹腔镜胆囊切除术患者作为研究对象，将其根据治疗方式的不同分为常规治疗组(对照组)75例和乳果糖组(观察组)75例。比较两组排气时间、排便时间，术前及术后2、5 d肠黏膜屏障及胃肠动力状态相关指标(餐前及餐后胃肠激素)。结果：观察组排气时间与排便时间均显著短于对照组(P<0.05)。两组术前肠黏膜屏障与胃肠动力状态相关指标比较，差异均无统计学意义(P>0.05);观察组术后2、5 d肠黏膜屏障与胃肠动力状态相关指标均显著优于对照组(P<0.05)。结论：乳果糖对腹腔镜胆囊切除术患者术后肠黏膜屏障与胃肠动力状态的影响更为积极，在本类手术患者中具有较高的应用价值。
【关键词】 乳果糖 腹腔镜胆囊切除术 肠黏膜屏障 胃肠动力状态
[Abstract] Objective： To study the influence of Lactosucrose for postoperative intestinal mucosal barrier and gastrointestinal motility state of patients with laparoscopic cholecystectomy. Method： A total of 150 patients with laparoscopic cholecystectomy treated in our hospital from September 2017 to March 2019 were chosen as the research objects， and they were divided into routine treatment group (the control group) 75 cases and Lactosucrose group (the observation group) 75 cases according to the differences of treatment methods. The exhaust time， defecation time， intestinal mucosal barrier and gastrointestinal motility state related indexes (gastrointestinal hormones before and after meal) before operation and 2， 5 d after operation of two groups were compared. Result： The exhaust time and defecation time of the observation group were significantly shorter than those of the control group (P<0.05). The intestinal mucosal barrier and gastrointestinal motility state related indexes of two groups before operation were compared， there were no statistically significant differences (P>0.05). The intestinal mucosal barrier and gastrointestinal motility state related indexes of the observation group 2， 5 d after operation were all significantly better than those of the control group (P<0.05). Conclusion： The influence of Lactosucrose for postoperative intestinal mucosal barrier and gastrointestinal motility state of patients with laparoscopic cholecystectomy are more active， so its application value in these surgical patients is higher.
腹腔镜胆囊切除术的临床应用率持续提升，而本类手术对患者的消化系统影响较为显著，因此患者术后的胃肠动力状态相对较差，相关的胃肠激素表现出较差的表达状态，而排气、排便时间等直观反映胃肠动力的指标具有更高的评估意义[1-2]。再者，肠黏膜屏障用于本类胃肠功能受影响较大患者的重要评估指标[3-4]。本研究就乳果糖对腹腔镜胆囊切除术后肠黏膜屏障及胃肠动力状态的影响进行探究，现报道如下。
1 资料与方法
1.1 一般资料 选取2017年9月-2019年3月本院收治的150例腹腔镜胆囊切除术患者作为研究对象。纳入标准：年龄18～80岁;性别不限;符合胆囊切除术手术指征;术前肝肾功能正常。排除标准：合并肝肾疾病;胃肠功能不全;合并冠心病、严重心律失常、心肌病等严重器质性疾病;合并自身免疫性疾病;合并恶性肿瘤;妊娠期或哺乳期;围术期应用肾毒性药物;围术期发生胆漏、胰腺炎及腹腔感染。将其根据治疗方式的不同分为常规治疗组(对照组)75例和乳果糖组(观察组)75例。该研究已经伦理学委员会批准。
1.2 方法 两组均进行常规腹腔镜胆囊切除术治疗，两组在手术方面基本相同。在此基础上，观察组于术后6 h应用乳果糖(生产厂家：北京韩美药品有限公司，批准文号：国药准字H20065730，规格：100 mL∶66.7 g)，10 mL/次，口服，3次/d。对照组给予10 mL温水口服。两组均应用7 d。两组的其他治疗及用药等均相同。, 百拇医药(陈文哲 肖强 张斌 吴君正 毛盛名)
【关键词】 乳果糖 腹腔镜胆囊切除术 肠黏膜屏障 胃肠动力状态
[Abstract] Objective： To study the influence of Lactosucrose for postoperative intestinal mucosal barrier and gastrointestinal motility state of patients with laparoscopic cholecystectomy. Method： A total of 150 patients with laparoscopic cholecystectomy treated in our hospital from September 2017 to March 2019 were chosen as the research objects， and they were divided into routine treatment group (the control group) 75 cases and Lactosucrose group (the observation group) 75 cases according to the differences of treatment methods. The exhaust time， defecation time， intestinal mucosal barrier and gastrointestinal motility state related indexes (gastrointestinal hormones before and after meal) before operation and 2， 5 d after operation of two groups were compared. Result： The exhaust time and defecation time of the observation group were significantly shorter than those of the control group (P<0.05). The intestinal mucosal barrier and gastrointestinal motility state related indexes of two groups before operation were compared， there were no statistically significant differences (P>0.05). The intestinal mucosal barrier and gastrointestinal motility state related indexes of the observation group 2， 5 d after operation were all significantly better than those of the control group (P<0.05). Conclusion： The influence of Lactosucrose for postoperative intestinal mucosal barrier and gastrointestinal motility state of patients with laparoscopic cholecystectomy are more active， so its application value in these surgical patients is higher.
腹腔镜胆囊切除术的临床应用率持续提升，而本类手术对患者的消化系统影响较为显著，因此患者术后的胃肠动力状态相对较差，相关的胃肠激素表现出较差的表达状态，而排气、排便时间等直观反映胃肠动力的指标具有更高的评估意义[1-2]。再者，肠黏膜屏障用于本类胃肠功能受影响较大患者的重要评估指标[3-4]。本研究就乳果糖对腹腔镜胆囊切除术后肠黏膜屏障及胃肠动力状态的影响进行探究，现报道如下。
1 资料与方法
1.1 一般资料 选取2017年9月-2019年3月本院收治的150例腹腔镜胆囊切除术患者作为研究对象。纳入标准：年龄18～80岁;性别不限;符合胆囊切除术手术指征;术前肝肾功能正常。排除标准：合并肝肾疾病;胃肠功能不全;合并冠心病、严重心律失常、心肌病等严重器质性疾病;合并自身免疫性疾病;合并恶性肿瘤;妊娠期或哺乳期;围术期应用肾毒性药物;围术期发生胆漏、胰腺炎及腹腔感染。将其根据治疗方式的不同分为常规治疗组(对照组)75例和乳果糖组(观察组)75例。该研究已经伦理学委员会批准。
1.2 方法 两组均进行常规腹腔镜胆囊切除术治疗，两组在手术方面基本相同。在此基础上，观察组于术后6 h应用乳果糖(生产厂家：北京韩美药品有限公司，批准文号：国药准字H20065730，规格：100 mL∶66.7 g)，10 mL/次，口服，3次/d。对照组给予10 mL温水口服。两组均应用7 d。两组的其他治疗及用药等均相同。, 百拇医药(陈文哲 肖强 张斌 吴君正 毛盛名)