顺德地区无偿献血人群开展不规则抗体筛查的研究(1)
【摘要】 目的：探究順德地区无偿献血人群开展不规则抗体筛查结果。方法：选取2018年2月-2020年
2月顺德地区无偿献血者25 029例，利用全自动凝聚胺微板法对其实施不规则抗体筛查，利用试剂谱抗体鉴定及效价测定细胞阳性标本。分析不规则抗体的检出情况。结果：本研究中的25 029例样本中，筛查出7例不规则抗体，其检出率为0.028%，另外规则抗体为25 022例，其检出率为99.972%;本研究中16 241例男性进行不规则抗体检查，其中检出的不规则抗体为4例，检出率为0.025%;8788例女性进行不规则抗体检查，其中检出不规则的抗体为3例，检出率为0.034%;女性无偿献血者中不规则抗体的阳性率与男性比较，差异无统计学意义(P>0.05)。7例不规则抗体中，IgG型1例，IgM型抗体6例，其中1例抗-D，2例抗-M，冷抗体4例。结论：随着输血医学技术的不断革新，对血型鉴定和抗体筛查成为临床输血中的必备部分。对顺德地区无偿献血者实施不规则抗体的检查，能够清楚认识到机体内不规则抗体所存在的频率、类型以及特异性、效价，能够促进电子交叉配血的实行，同时为顺德地区临床输血提供真实的数据支持，保障了临床用血安全、有效和及时的特性，值得推广应用。
【关键词】 无偿献血人群 不规则抗体 筛查
[Abstract] Objective： To explore the results of irregular antibody screening among free blood donors in Shunde area. Method： A total of 25 029 free blood donors in Shunde area from February 2018 to February 2020 were selected. It was screened for irregular antibodies by automatic polyamine microplate method. The positive samples were identified by reagent spectrum antibody and titer. The detection of irregular antibody was analyzed. Result： Among the 25 029 samples in this study， 7 irregular antibodies were screened， with a detection rate of 0.028%， in addition， 25 022 cases were regular antibody， the detection rate was 99.972%. In this study， 16 241 male patients were examined for irregular antibodies， 4 of them were irregular antibodies， the detection rate was 0.025%. 8，788 women were examined for irregular antibodies， 3 of them were irregular antibodies， the detection rate was 0.034%. The positive rate of irregular antibody in female unpaid blood donors was compared with that in male， there was no significant difference (P>0.05). Among 7 cases of irregular antibodies， 1 case of IgG type and 6 cases of IgM type antibody， including 1 case of anti-D， 2 cases of anti-M and 4 cases of cold antibody. Conclusion： With the continuous innovation of transfusion medical technology， blood group identification and antibody screening become an essential part of clinical transfusion. Irregular antibody tests are carried out on blood donors in Shunde area， it can clearly recognize the frequency， type， specificity and titer of irregular antibodies in the body， promote the implementation of electronic cross matching， provide real data support for clinical blood transfusion in Shunde area， and ensure the safety， effectiveness and timeliness of clinical blood use， which is worthy of promotion and application.
[Key words] Free blood donors Irregular antibody Screening
First-author’s address： Foshan City Shunde District Central Blood Station， Foshan 528300， China, 百拇医药(梁丽雯 叶伟亮 刘志泉 李交 陈永飞 于艳涛)
2月顺德地区无偿献血者25 029例，利用全自动凝聚胺微板法对其实施不规则抗体筛查，利用试剂谱抗体鉴定及效价测定细胞阳性标本。分析不规则抗体的检出情况。结果：本研究中的25 029例样本中，筛查出7例不规则抗体，其检出率为0.028%，另外规则抗体为25 022例，其检出率为99.972%;本研究中16 241例男性进行不规则抗体检查，其中检出的不规则抗体为4例，检出率为0.025%;8788例女性进行不规则抗体检查，其中检出不规则的抗体为3例，检出率为0.034%;女性无偿献血者中不规则抗体的阳性率与男性比较，差异无统计学意义(P>0.05)。7例不规则抗体中，IgG型1例，IgM型抗体6例，其中1例抗-D，2例抗-M，冷抗体4例。结论：随着输血医学技术的不断革新，对血型鉴定和抗体筛查成为临床输血中的必备部分。对顺德地区无偿献血者实施不规则抗体的检查，能够清楚认识到机体内不规则抗体所存在的频率、类型以及特异性、效价，能够促进电子交叉配血的实行，同时为顺德地区临床输血提供真实的数据支持，保障了临床用血安全、有效和及时的特性，值得推广应用。
【关键词】 无偿献血人群 不规则抗体 筛查
[Abstract] Objective： To explore the results of irregular antibody screening among free blood donors in Shunde area. Method： A total of 25 029 free blood donors in Shunde area from February 2018 to February 2020 were selected. It was screened for irregular antibodies by automatic polyamine microplate method. The positive samples were identified by reagent spectrum antibody and titer. The detection of irregular antibody was analyzed. Result： Among the 25 029 samples in this study， 7 irregular antibodies were screened， with a detection rate of 0.028%， in addition， 25 022 cases were regular antibody， the detection rate was 99.972%. In this study， 16 241 male patients were examined for irregular antibodies， 4 of them were irregular antibodies， the detection rate was 0.025%. 8，788 women were examined for irregular antibodies， 3 of them were irregular antibodies， the detection rate was 0.034%. The positive rate of irregular antibody in female unpaid blood donors was compared with that in male， there was no significant difference (P>0.05). Among 7 cases of irregular antibodies， 1 case of IgG type and 6 cases of IgM type antibody， including 1 case of anti-D， 2 cases of anti-M and 4 cases of cold antibody. Conclusion： With the continuous innovation of transfusion medical technology， blood group identification and antibody screening become an essential part of clinical transfusion. Irregular antibody tests are carried out on blood donors in Shunde area， it can clearly recognize the frequency， type， specificity and titer of irregular antibodies in the body， promote the implementation of electronic cross matching， provide real data support for clinical blood transfusion in Shunde area， and ensure the safety， effectiveness and timeliness of clinical blood use， which is worthy of promotion and application.
[Key words] Free blood donors Irregular antibody Screening
First-author’s address： Foshan City Shunde District Central Blood Station， Foshan 528300， China, 百拇医药(梁丽雯 叶伟亮 刘志泉 李交 陈永飞 于艳涛)