无创正压通气辅助常规治疗阻塞性睡眠呼吸暂停低通气综合征的效果及对hs-CRP、Hcy及NO水平的影响(1)
【摘要】 目的：探討无创正压通气辅助常规治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的效果及对超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)及一氧化氮(NO)水平的影响。方法：选取本院2017年12月-2018年11月收治的66例OSAHS患者为研究对象，按照随机数字表法分为对照组与研究组，各33例。对照组进行常规治疗，研究组在对照组基础上进行无创正压通气辅助治疗。比较干预前后两组多导睡眠监测相关指标、睡眠质量、嗜睡情况、糖脂代谢指标、NO、Hcy及hs-CRP水平。结果：干预后，两组最低SaO2与平均SaO2均高于干预前，而呼吸暂停低通气指数低于干预前(P<0.05)。干预后，研究组最低SaO2与平均SaO2均高于对照组，而呼吸暂停低通气指数低于对照组(P<0.05)。干预后，两组睡眠匹兹堡睡眠质量指数(PSQI)与Epworth嗜睡量表(ESS)评分均低于干预前，且研究组ESS与SQI评分均低于对照组(P<0.05)。干预后，两组空腹血糖(FBG)、餐后2 h血糖(2 h PG)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C)水平均低于干预前，而高密度脂蛋白胆固醇(HDL-C)水平高于干预前(P<0.05)。干预后，研究组FBG、2 h PG、TG及LDL-C水平均低于对照组，而HDL-C水平高于对照组(P<0.05)。干预后，两组Hcy与hs-CRP水平均低于干预前，而NO水平高于干预前(P<0.05)。干预后，研究组Hcy与hs-CRP水平均低于对照组，而NO水平高于对照组(P<0.05)。结论：无创正压通气辅助常规治疗可显著改善OSAHS患者睡眠质量及嗜睡情况，纠正体内糖脂代谢紊乱，升高血清NO水平，降低血清hs-CRP、Hcy水平。
【关键词】 阻塞性睡眠呼吸暂停低通气综合征 无创正压通气 超敏C反应蛋白 同型半胱氨酸
[Abstract] Objective： To investigate the effect of noninvasive positive pressure ventilation assisted conventional treatment on obstructive sleep apnea hypopnea syndrome (OSAHS) and its effects on the levels of hypersensitive C-reactive protein (hs-CRP)， homocysteine (Hcy) and nitric oxide (NO). Method： A total of 66 OSAHS patients admitted to our hospital from December 2017 to November 2018 were selected as the study objects. According to the random number table method， they were divided into the control group and the study group， 33 cases in each group. The control group was treated with routine treatment， and the study group was treated with noninvasive positive pressure ventilation on the basis of the control group. The indexes of polysomnography， sleep quality， drowsiness， glycolipid metabolism， NO， Hcy and hs-CRP of two groups were compared before and after the intervention. Result： After intervention， the lowest and average SaO2 of the two groups were higher than those before intervention， while the apnea hypopnea index of the two groups were lower than those before intervention (P<0.05). After intervention， the lowest and average SaO2 of the study group were higher than those of the control group， while the apnea hypopnea index was lower than that of the control group (P<0.05). After intervention， both Pittsburg sleep quality index (PSQI) and Epworth sleepiness scale (ESS) scores of the two groups were lower than those before intervention， the ESS and SQI scores of the study group were lower than those in the control group (P<0.05). After intervention， fasting blood glucose (FBG)， postpranational 2 h plasma glucose (2 h PG)， triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels in both groups were lower than those before intervention， while high density lipoprotein cholesterol (HDL-C) levels in both groups were higher than those before intervention (P<0.05). After intervention， FBG， 2 h PG， TG and LDL-C levels in the study group were lower than those in the control group， while HDL-C level was higher than that in the control group (P<0.05). After intervention， Hcy and hs-CRP levels in both groups were lower than before intervention， while NO levels in both groups were higher than those before intervention (P<0.05). After intervention， Hcy and hs-CRP levels in the study group were lower than those in the control group， while NO levels was higher than that in the control group (P<0.05). Conclusion： Noninvasive positive pressure ventilation assisted conventional treatment can significantly improve the sleep quality and sleepiness of OSAHS patients， correct the disorder of glucose and lipid metabolism， increase the level of serum NO， reduce the levels of serum hs-CRP and Hcy., 百拇医药(邓杰方 黄穗华 董敬军)
【关键词】 阻塞性睡眠呼吸暂停低通气综合征 无创正压通气 超敏C反应蛋白 同型半胱氨酸
[Abstract] Objective： To investigate the effect of noninvasive positive pressure ventilation assisted conventional treatment on obstructive sleep apnea hypopnea syndrome (OSAHS) and its effects on the levels of hypersensitive C-reactive protein (hs-CRP)， homocysteine (Hcy) and nitric oxide (NO). Method： A total of 66 OSAHS patients admitted to our hospital from December 2017 to November 2018 were selected as the study objects. According to the random number table method， they were divided into the control group and the study group， 33 cases in each group. The control group was treated with routine treatment， and the study group was treated with noninvasive positive pressure ventilation on the basis of the control group. The indexes of polysomnography， sleep quality， drowsiness， glycolipid metabolism， NO， Hcy and hs-CRP of two groups were compared before and after the intervention. Result： After intervention， the lowest and average SaO2 of the two groups were higher than those before intervention， while the apnea hypopnea index of the two groups were lower than those before intervention (P<0.05). After intervention， the lowest and average SaO2 of the study group were higher than those of the control group， while the apnea hypopnea index was lower than that of the control group (P<0.05). After intervention， both Pittsburg sleep quality index (PSQI) and Epworth sleepiness scale (ESS) scores of the two groups were lower than those before intervention， the ESS and SQI scores of the study group were lower than those in the control group (P<0.05). After intervention， fasting blood glucose (FBG)， postpranational 2 h plasma glucose (2 h PG)， triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels in both groups were lower than those before intervention， while high density lipoprotein cholesterol (HDL-C) levels in both groups were higher than those before intervention (P<0.05). After intervention， FBG， 2 h PG， TG and LDL-C levels in the study group were lower than those in the control group， while HDL-C level was higher than that in the control group (P<0.05). After intervention， Hcy and hs-CRP levels in both groups were lower than before intervention， while NO levels in both groups were higher than those before intervention (P<0.05). After intervention， Hcy and hs-CRP levels in the study group were lower than those in the control group， while NO levels was higher than that in the control group (P<0.05). Conclusion： Noninvasive positive pressure ventilation assisted conventional treatment can significantly improve the sleep quality and sleepiness of OSAHS patients， correct the disorder of glucose and lipid metabolism， increase the level of serum NO， reduce the levels of serum hs-CRP and Hcy., 百拇医药(邓杰方 黄穗华 董敬军)