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编号:13820968
不同剂量二甲双胍联合阿格列汀治疗2型糖尿病合并骨质疏松症患者的疗效研究(1)
http://www.100md.com 2020年8月5日 《中国医学创新》 202022
     【摘要】 目的:評价不同剂量的二甲双胍联合阿格列汀对2型糖尿病合并骨质疏松患者的治疗价值。方法:选取2017年10月-2018年10月于本院就诊并确诊为2型糖尿病合并骨质疏松症的门诊及住院患者83例。根据随机数字表法分为A组40例和B组43例。A组给予二甲双胍1 g/次,2次/d;B组给予二甲双胍0.5 g/次,2次/d;两组均同时给予苯甲酸阿格列汀25 mg/次,1次/d。比较两组治疗前后的血糖、骨代谢、骨密度,观察两组并发症发生情况。结果:治疗6、12个月后,A组FBG、2 h PG、HbA1c水平均低于B组,差异均有统计学意义(P<0.05)。治疗12个月后,A组PⅠNP水平高于B组,β-CTX水平低于B组,差异均有统计学意义(P<0.05)。治疗12个月后,A组L4-BMD、FW-BMD均高于治疗前,且均高于B组,差异均有统计学意义(P<0.05)。治疗12个月后,A组骨折发生率为2.50%,总并发症发生率为5.00%,均低于B组的16.28%、20.93%,差异均有统计学意义(P<0.05)。结论:服用1 g/次,2次/d剂量的二甲双胍联合阿格列汀治疗2型糖尿病合并骨质疏松症具有良好疗效。

    【关键词】 二甲双胍 阿格列汀 不同剂量 2型糖尿病合并骨质疏松 疗效 影响

    Efficacy of Different Doses of Metformin Combined with Alogliptin in the Treatment of Type 2 Diabetes Mellitus Complicated with Osteoporosis/WANG Yang, HONG Shihua, KE Ruiqiong, GUO Li, HONG Huanshan, LIAO Yuhua. //Medical Innovation of China, 2020, 17(22): 0-043

    [Abstract] Objective: To evaluate the therapeutic value of different doses of Metformin combined with Agliptin in patients with type 2 diabetes mellitus complicated with osteoporosis. Method: A total of 83 outpatient and inpatient patients diagnosed with type 2 diabetes combined with osteoporosis were selected from October 2017 to October 2018. According to the random number table method, 40 cases were divided into group A and 43 cases were divided into group B. Group A was given Metformin 1 g/ time and 2 times /day. In group B, Metformin was given 0.5 g/ time and 2 times /day. Agliptin Benzoate was given 25 mg/ time and 1 time /day in both groups. Blood glucose, bone metabolism and bone density of the two groups were compared before and after treatment, the complications of the two groups were observed. Result: After 6 months and 12 months of treatment, the levels of FBG, 2 h PG and HbA1c in group A were lower than those in group B, the differences were statistically significant (P<0.05). After 12 months of treatment, the level of PⅠNP in group A was higher than that in group B, the β-CTX level was lower than group B, the differences were statistically significant (P<0.05). After 12 months of treatment, L4-BMD and FW-BMD in group A were both higher than those before treatment, and higher than those in group B, with statistically significant differences (P<0.05). After 12 months of treatment, the fracture rate of group A was 2.50%, and the total complication rate was 5.00%, which were lower than 16.28% and 20.93% of group B, the differences were statistically significant (P<0.05). Conclusion: Taking Metformin and Agliptin at doses of 1 g/ time and 2 times /day has a good effect in the treatment of type 2 diabetes with osteoporosis., 百拇医药(王瑒 洪世华 柯瑞琼 郭莉 洪欢山 廖玉华)
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