利拉鲁肽对不同体重指数2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量及血清FGF-21的影响(4)
[9] Kezhong Zhang，Xiaohua Shen，Jun Wu，et al.Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response[J].Cell，2006，124(3)：587-599.
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[11] Salminen A，Kauppinen A，Kaarniranta K，et al.FGF21 activates AMPK signaling： impact on metabolic regulation and the aging process[J].Journal of Molecular Medicine，2017，95(2)：123-131.
[12]武繼承，郭林峰，唐道琪，等.GLP-1受体激动剂的临床药效与安全性研究进展[J].药物生物技术，2016，23(4)：367-371.
[13] Jeon J Y，Choi S E，Ha E S，et al.Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles[J].Endocrine，2016，53(1)：97-106.
[14] Lee J，Hong S W，Park S E，et al.Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis[J].Metabolism，2014，63(8)：1041-1048.
[15] Markan K R，Naber M C，Small S M，et al.FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue[J].Mol Metab，2017，6(6)：602-610.
(收稿日期：2020-02-04) (本文编辑：张爽), http://www.100md.com(王欣 王国君)
[10] Tanaka N，Takhashi S，Zhang Y，et al.Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine and choline-deficient diet[J].Biochimica Et Biophysica Acta，2015，1852(7)：1242-1252.
[11] Salminen A，Kauppinen A，Kaarniranta K，et al.FGF21 activates AMPK signaling： impact on metabolic regulation and the aging process[J].Journal of Molecular Medicine，2017，95(2)：123-131.
[12]武繼承，郭林峰，唐道琪，等.GLP-1受体激动剂的临床药效与安全性研究进展[J].药物生物技术，2016，23(4)：367-371.
[13] Jeon J Y，Choi S E，Ha E S，et al.Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles[J].Endocrine，2016，53(1)：97-106.
[14] Lee J，Hong S W，Park S E，et al.Exendin-4 regulates lipid metabolism and fibroblast growth factor 21 in hepatic steatosis[J].Metabolism，2014，63(8)：1041-1048.
[15] Markan K R，Naber M C，Small S M，et al.FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue[J].Mol Metab，2017，6(6)：602-610.
(收稿日期：2020-02-04) (本文编辑：张爽), http://www.100md.com(王欣 王国君)