刘欣金 龚立勤

    【摘要】 目的：探讨乳腺癌化疗性肝损伤的相关危险因素。方法：选择2015年1月-2019年12月在本院接受化疗的106例乳腺癌患者的资料进行回顾性分析。对全部患者发生化疗性肝损伤的情况进行描述。按照患者是否发生化疗性肝损伤分组，分为病例组33例和对照组73例。通过单因素分析与多因素分析的方式，筛选乳腺癌化疗性肝损伤的相关危险因素。结果：2015年1月-2019年12月在本院接受化疗的乳腺癌患者共106例，33例患者发生化疗性肝损伤，发病率为31.13%。年龄、BMI、化疗方案、乙肝病毒感染、糖尿病是乳腺癌患者发生化疗性肝损伤的独立危险因素(P<0.05)。结论：多种因素均可导致乳腺癌患者出现化疗性肝损伤，需要进行具有针对性的干预。

    【关键词】 乳腺癌 化疗性肝损伤 恶性肿瘤 毒副反应

    Study on Risk Factors Associated with Chemotherapy-induced Liver Injury in Breast Cancer/LIU Xinjin， GONG Liqin. //Medical Innovation of China， 2021， 18(05)： -136

    [Abstract] Objective： To investigate the risk factors associated with chemotherapy-induced liver injury in breast cancer. Method： The data of 106 breast cancer patients who received chemotherapy in our hospital from January 2015 to December 2019 were retrospectively analyzed. The occurrence of chemotherapy-induced liver injury in all patients were described. Patients were divided into case group (n=33) and control group (n=73) according to the occurrence of chemotherapy-induced liver injury. Univariate analysis and multivariate analysis were used to screen the risk factors of breast cancer chemotherapy-induced liver injury. Result： In January 2015 to December 2019 ......