陈麒竹 戴德 罗国庆

    【摘要】 喉癌是耳鼻咽喉科常见的恶性肿瘤，不断地有研究证明咽喉反流是导致喉癌的致病因素之一。应用抑酸药物治疗咽喉反流物未能达到预期效果，人们发现咽喉反流物中胃蛋白酶较稳定地存在，且在非酸性环境下仍可损伤喉部黏膜细胞。在喉癌组织中胃蛋白酶的表达较正常组织增多。治疗上发现胃蛋白酶抑制剂于咽喉反流治疗是有效的，减少喉细胞损伤进而减少喉癌的发生。

    【关键词】 喉癌 咽喉反流 胃蛋白酶

    [Abstract] Laryngeal cancer is a common malignant tumor in otorhinolaryngology， it has been proved that laryngopharyngeal reflux is one of the pathogenic factors of laryngeal cancer. When treatment with acid suppression drugs failed to achieve the desired effect， it has been found that pepsin is stable in the throat reflux， and it can still damage the laryngeal mucosa cells in non acid environment. The expression of pepsin in laryngeal carcinoma was higher than that in normal tissues. It is found that pepsin inhibitor is effective in the treatment of laryngopharyngeal reflux， which can reduce the damage of laryngeal cells and the occurrence of laryngeal cancer.

    [Key words] Laryngeal cancer Laryngopharyngeal reflux Pepsin

    First-authors address： Guangdong Medical University， Zhanjiang 524000， China

    doi：10.3969/j.issn.1674-4985.2021.06.045

    喉癌是耳鼻咽喉科常见的惡性肿瘤之一 ......