周雯雯

    【摘要】 目的：探討大剂量维生素C联合阿奇霉素治疗肺炎支原体感染的效果及对患儿白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平的影响。方法：选取2019年1-12月在本院诊治的124例肺炎支原体肺炎(MPP)患儿，按照随机数字表法将患儿分为对照组和观察组，每组62例。在对症支持治疗的基础上，对照组患儿给予阿奇霉素治疗，观察组患儿给予阿奇霉素联合大剂量维生素C治疗。比较两组患儿疗效和炎症相关指标，分析患儿体征、症状缓解情况和肺功能指标，观察患儿不良反应发生情况。结果：观察组总有效率为95.16%，明显高于对照组的77.42%，差异有统计学意义(P0.05)。治疗后，两组的FVC、PEF、FEV1/FVC%水平均升高，观察组均明显高于对照组，差异均有统计学意义(P0.05)。结论：MPP患儿给予大剂量维生素C联合阿奇霉素治疗，效果显著，减少了炎症反应，可有效缓解临床症状和体征，改善肺功能，提升安全性。

    【关键词】 肺炎支原体肺炎 大剂量维生素C 阿奇霉素 肺功能

    [Abstract] Objective： To investigate the efficacy of high dose Vitamin C combined with Azithromycin in the treatment of mycoplasma pneumoniae infection and its influence on the levels of IL-6， TNF-α and CRP in children. Method： A total of 124 children with mycoplasma pneumoniae pneumonia (MPP) in our hospital from January to December 2019 were selected， they were divided into the control group and observation group， according to random number table method， 62 cases in each group. On the basis of symptomatic supportive treatment ......