穆艳顺

    【摘要】 新生儿缺氧缺血性脑病是造成新生儿致残及死亡的主要原因之一。随着新生儿急救水平的发展，新生儿缺氧性脑病患儿存活率显著提高。然而，新生儿缺氧缺血性脑病易导致神经系统发育障碍如脑瘫、癫痫及发育迟缓等，给患儿及其家庭、社会造成沉重负担。目前新生儿缺氧性脑病的各类检测方法都有优缺点，有部分患儿神经影像学检查无异常，却发展为脑瘫。因此，需要有更为敏感及特异度高的神经标志物来指导临床。为了更好地运用这些神经标志物对临床做指导，本研究将把神经标志物在新生儿缺氧缺血性脑病诊断的应用进行综述。

    【关键词】 新生儿 缺氧缺血性脑病 神经标志物

    [Abstract] Neonatal hypoxic ischemic encephalopathy is still one of the main causes of neonatal disability and death. With the development of the level of first aid for newborns， the survival rate of newborns with brain injury has been significantly improved. At the same time， neonatal hypoxic ischemic encephalopathy can easily lead to nervous system development disorders such as cerebral palsy， epilepsy and growth retardation， which cause serious burden to the children， their families and society. At present， all kinds of detection methods of neonatal hypoxic ischemic encephalopathy have their advantages and disadvantages， some children have no abnormal neuroimaging examination， but develop into children with cerebral palsy. Therefore， more sensitive and specific nerve markers are needed to guide clinical practice. In order to better use these nerve markers for clinical guidance ......