刘士平 张雪利

    【摘要】 目的：探究高压氧治疗急性脑梗死的临床效果及对急性时相反应蛋白、糖化血红蛋白的影响。方法：选取2018年1月-2020年6月本院收治的90例急性脑梗死患者为研究对象。将患者随机分为对照组和观察组，每组45例。对照组采用常规脑梗死治疗，观察组在对照组的基础上加用高压氧治疗。比较两组治疗后不同时间的临床效果，比较两组治疗前后的血清神经损伤相关指标(NSE、S100B)及急性时相反应蛋白(SAA、hs-CRP)、糖化血红蛋白(HbA1c)水平。结果：出院时和出院后15、30 d，观察组的临床总有效率均显著高于对照组，差异均有统计学意义(P<0.05)。治疗前，两组的血清神经损伤相关指标、急性时相反应蛋白及HbA1c水平比较，差异均无统计学意義(P>0.05);治疗10、20、30 d后，观察组的血清神经损伤相关指标、急性时相反应蛋白及HbA1c水平均显著低于对照组，差异均有统计学意义(P<0.05)。结论：高压氧治疗急性脑梗死的临床效果较好，可有效控制急性时相反应蛋白及HbA1c水平，在急性脑梗死患者中的应用价值较高。

    【关键词】 高压氧 急性脑梗死 急性时相反应蛋白 糖化血红蛋白

    [Abstract] Objective： To investigate the clinical effect of Hyperbaric oxygen therapy in the treatment of acute cerebral infarction and its effect on acute phase response protein and glycosylated hemoglobin. Method： A total of 90 patients with acute cerebral infarction admitted to our hospital from January 2018 to June 2020 were selected as the research subjects. The patients were randomly divided into control group and observation group， 45 cases in each group. The control group was treated with conventional cerebral infarction and the observation group was treated with Hyperbaric oxygen therapy on the basis of the control group. The clinical effect of the two groups at different time after treatment were compared. Serum nerve injury-related indexes (NSE ......