石喆 任珊 戴文斌

    【摘要】 乳腺癌是全世界女性最常见的恶性肿瘤之一，高危型人乳头瘤病毒(human papillomavirus， HPV)已被证实存在于乳腺癌及其癌前病变和正常乳腺组织中，但也有研究结果得出相反的结论。HPV与乳腺癌病因学的关系仍存在较大的争议，慢性炎症可以通过病毒致癌微生物途径在肿瘤微环境中启动，Toll样受体(Toll-like receptors， TLRs)介导的核因子-κB(nuclear factor kappa B， NF-κB)和干扰素调节因子(interferon regulatory factors， IRFs)的激活是炎症与癌症之间的重要联系，激活TLRs/NF-κB信号通路有助于肿瘤进展，TLRs基因多态性与乳腺癌的易感性有关，可促进乳腺癌细胞的增殖、浸润和转移，进而影响乳腺癌的发生发展。TLR可能成为乳腺癌治疗的潜在药物治疗靶点。本文结合最新文献，对HPV感染及其与TLRs关系的研究进展予以阐述。

    【关键词】 乳腺癌 人乳头瘤病毒 TLR NF-κB

    [Abstract] Breast cancer is one of the most common malignancies in women worldwide. High-risk human papillomavirus (HPV) has been identified in human breast cancer， precancerous lesions and normal breast tissue， but some studies have shown the opposite conclusion. The relationship between HPV and the etiology of human breast cancer is still controversial， chronic inflammation can be initiated in the tumor microenvironment through the cancer-causing microorganisms of the virus， toll-like receptors (TLRs)-mediated activation of nuclear factor kappa B (NF-κB) and interferon regulatory factors (IRFs) is an important link between inflammation and cancer. Activation of TLRs/NF-κB signaling pathway contributes to tumor progression ......