袁向阳 王翔 戴淼

    【关键词】 间断利尿 慢性心力衰竭 利尿剂抵抗

    [Abstract] Objective： To investigate the mechanism of intermittent diuresis in preventing diuretic resistance of chronic heart failure. Method： A total of 20 rats of 8 to 10 weeks old with heart failure by constricting ascending aorta were as the study objects， and they were randomly divided into continuous diuresis group and intermittent diuresis group， 10 rats in each group. Then the blood indexes (PRA， Ang-Ⅱ， ALD and NT-proBNP) and echocardiography results (HR， LVEDD， LVESD， EF， LVFS， LVAWD/S and LVPWD/S) at experimental starting point， the 6th， 12th， 16th and 20th week， renal distal convoluted tubule hyperplasia situation and myocardial fibrosis situation of two groups were compared. Result： The blood indexes and echocardiography results of two groups at experimental starting point were compared， there were no statistically significant differences (P>0.05). The blood indexes and echocardiography results of intermittent diuresis group at the 6th ......