于金璐 韩明月 陈佳琳 王强

    【摘要】 血小板反应蛋白(thrombospondin，TSP)作为一种基质细胞蛋白，分为A和B亚群。它们可与多种配体相互作用，调节各种生理和病理过程。TSP在眼睛很多部位中表达，可参与免疫调节、抗血管和淋巴管生成、伤口愈合以及神经元突触形成等。越来越多的研究证明了TSP各种亚型的缺乏将会导致眼部稳态破坏和眼部疾病发生。本文主要回顾了TSP各亚型的特性、功能以及其在青光眼、糖尿病视网膜病变、干眼、眼部过敏、角膜移植和感染性角膜炎等疾病中发挥的作用。

    【关键词】 血小板反应蛋白 眼科疾病 生理 病理

    Latest Research Progress of Platelet Reactive Protein in Ophthalmological Related Diseases/YU Jinlu， HAN Mingyue， CHEN Jialin， WANG Qiang. //Medical Innovation of China， 2021， 18(28)： -183

    [Abstract] As a kind of stromal cell protein， the thrombospondin (TSP) can be divided into A and B inferior populations. They can interact with a variety of ligands to regulate a variety of physiological and pathological processes. TSP is expressed in many parts of the eye and is involved in immune regulation， anti-angiogenesis and Anti-lymphangiogenesis， wound healing， and neuronal synapse formation. More and more studies have demonstrated that the lack of various subtypes of TSP will lead to impaired ocular homeostasis and ophthalmological disease. In this article ......