陈忠锐

    【摘要】 目的：探討NT-proBNP、HGF和GDF-15在射血分数保留型心衰(HFpEF)患者中的表达及其预测价值。方法：选择2018年7月-2019年3月于本院就诊的慢性心力衰竭患者100例，根据患者左室射血分数是否>50%分为HFpEF组和射血分数降低型心衰(HFrEF)组，同时将50例同期住院心功能正常者作为对照组。收集三组患者病史、心功能、生化指标、血常规、N末端脑钠肽(NT-proBNP)、肝细胞生长因子(hepatocyte growth factor，HGF)、生长分化因子-15(growth differentiation factor-15，GDF-15)等临床资料;采用多元logistic回归分析HFpEF的危险因素，并绘制ROC曲线比较诊断价值;比较HFpEF组和HFrEF组发生主要心血管不良事件(MACE)和未发生MACE患者的NT-proBNP、GDF-15和HGF水平。结果：三组性别、心率、心功能分级、NT-proBNP、肌钙蛋白、尿酸、房颤病史、GDF-15、HGF比较，差异均有统计学意义(P50%， and 50 patients with normal cardiac function in the same period were selected as the control group. The medical history， cardiac function， biochemical indexes， blood routine， N-terminal brain natriuretic peptide (NT-proBNP)， hepatocyte growth factor (HGF)， growth differentiation factor-15 (GDF-15) and other clinical data of three groups were collected; multivariate logistic regression was used to analyze the risk factors of HFpEF ......