孙妍 王露

    【摘要】 目的：探究卡格列净联合二甲双胍对2型糖尿病(T2DM)合并非酒精性脂肪肝患者血尿酸及胰岛素抵抗的影响。方法：选取2019年2-12月于本院78例糖尿病病房住院的T2DM合并NAFLD患者，将住院病例号码采用随机数字表法分为二甲双胍组和联合用药组，每组39例。两组均接受保肝、降脂、监测血糖、控制饮食等基础治疗。二甲双胍组在基础治疗的基础上加用二甲双胍。联合用药组在对照组的基礎上加用卡格列净。比较两组治疗前后血尿酸、空腹胰岛素、胰岛素抵抗、空腹血糖、餐后2 h血糖、甘油三酯、总胆固醇水平。结果：治疗前，两组血尿酸、空腹胰岛素、胰岛素抵抗指数、空腹血糖及餐后2 h血糖、总胆固醇和甘油三酯比较，差异无统计学意义(P>0.05);治疗后，两组血尿酸、空腹胰岛素、胰岛素抵抗指数、空腹血糖及餐后2 h血糖、总胆固醇和甘油三酯均低于治疗前，且联合用药组均低于二甲双胍组，差异均有统计学意义(P<0.05)。结论：卡格列净联合二甲双胍可降低2型糖尿病合并非酒精性脂肪肝患者血尿酸，改善胰岛素抵抗。

    【关键词】 2型糖尿病 非酒精性脂肪肝 血尿酸 胰岛素抵抗

    Effects of Canagliflozin Combined with Metformin on Blood Uric Acid and Insulin Resistance in Patients with Type 2 Diabetes Mellitus Complicated with Non-alcoholic Fatty Liver Disease/SUN Yan， WANG Lu. //Medical Innovation of China， 2021， 18(30)： -124

    [Abstract] Objective： To explore the effect of Canagliflozin combined with Metformin on blood uric acid and insulin resistance in patients with type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease. Method： A total of 78 patients with T2DM complicated with NAFLD in the diabetes ward of our hospital from February to December 2019 were selected ......