方幸 刘雪琳 丁培丽

    【摘要】 洋葱伯克霍尔德菌是临床常见的机会致病菌，其感染多见于肺囊性纤维化及免疫抑制患者，可引起呼吸系统、泌尿系统、血流感染、颅内感染等，尤其肺内感染造成不可逆的肺組织损伤。目前对于洋葱伯克霍尔德菌治疗的抗生素选择较少，同时由于其耐药率高，很难被清除，因此临床对于洋葱伯克霍尔德菌感染的治疗手段有限且效果不佳。本文就该细菌的耐药机制进行总结，为基础及临床研发并使用抗菌药物提供相关思路。

    【关键词】 洋葱伯克霍尔德菌 耐药 外膜通透屏障 外排泵系统 β-内酰胺酶

    Research on Drug Resistance Mechanism of Burkholderia Cepacia/FANG Xing， LIU Xuelin， DING Peili. //Medical Innovation of China， 2021， 18(32)： -188

    [Abstract] Burkholderia cepacia is one of the most common clinical opportunistic pathogens， it often affects patients with pulmonary cystic fibrosis and the patients who are in immunosuppression， it can cause respiratory， urinary， bloodstream， and intracranial infections， especially in the lungs， the infection causes irreversible lung tissue damage. At present， there are few antibiotics for the treatment of Burkholderia cepacia， at the same time， due to its high drug resistance rate， it is difficult to be eliminated， therefore， the clinical treatment of Burkholderia cepacia infection is limited and the effect is not good. This article summarize the drug resistance mechanism of this kind of bacteria ......