【摘要】 目的：探討贝达喹啉对糖尿病伴耐药肺结核患者痰菌转阴及血糖控制情况的影响。方法：回顾性分析2017年1月-2018年1月本院174例糖尿病合并肺结核患者的临床资料，根据治疗方法分为常规治疗组(n=42)和联合治疗组(n=132)。常规治疗组采用常规治疗，联合治疗组在常规治疗组的基础上加用贝达喹啉。比较两组痰菌转阴率及血糖控制情况。结果：联合治疗组转阴率为74.24%(98/132)，高于常规治疗组的50.00%(21/42)，差异有统计学意义(P<0.05)。治疗前，两组FPG、2 h PG及HbA1c水平比较，差异均无统计学意义(P>0.05);治疗后，联合治疗组FPG、2 h PG及HbA1c水平均低于常规治疗组，差异均有统计学意义(P<0.05)。结论：贝达喹啉用于糖尿病患者合并耐药肺结核患者中，有助于提高痰菌转阴率，能更好地控制患者血糖水平，值得推广应用。

    【关键词】 糖尿病 耐药肺结核 贝达喹啉 痰菌转阴 血糖控制

    Effect of Bedaquinoline on Sputum Negative Conversion and Blood Glucose Control in Diabetic Patients with Drug-Resistant Pulmonary Tuberculosis/LIU Xianwei. //Medical Innovation of China， 2021， 18(34)： -153

    [Abstract] Objective： To investigate the effect of Bedaquinoline on sputum negative conversion and blood glucose control in diabetic patients with drug-resistant pulmonary tuberculosis. Method： The clinical data of 174 patients with diabetes and drug-resistant pulmonary tuberculosis in our hospital from January 2017 to January 2018 were retrospectively analyzed. They were divided into conventional treatment group (n=42) and combination treatment group (n=132) according to the treatment methods. The conventional treatment group was treated with conventional treatment ......