邹连玉 郑丽维

    【摘要】 目前，我国高血压具有患病率高，控制率低的特点，是全球心血管疾病死亡的主要疾病负担，高血压防治任重道远，亟待寻求突破。近年研究发现，具有调控细胞活动、能量代谢及蛋白合成等重要生理过程的PI3K/AKt信号通路在高血压防治过程中扮演着重要角色。因此，本文将以PI3K/AKt信号通路在高血压防治中的调控作用展开综述，旨在探讨PI3K/AKt信号通路在高血压中的临床价值与研究不足，以期为今后高血压的防治提供新思路。

    【关键词】 PI3K/AKt 高血压 内皮细胞 心肌细胞

    Research Progress of PI3K/ AKt Signaling Pathway in the Prevention and Treatment of Hypertension Diseases/ZOU Lianyu， ZHENG Liwei. //Medical Innovation of China， 2021， 18(34)： -179

    [Abstract] At present， hypertension in China is characterized by high prevalence rate and low control rate， and it is the main disease burden of cardiovascular disease death in the world. Therefore， there is a long way to go in the prevention and treatment of hypertension， and it is urgent to seek a breakthrough. Recent studies have found that PI3K/AKt signaling pathway， which regulates important physiological processes such as cell activity， energy metabolism and protein synthesis， plays an important role in the prevention and treatment of hypertension. Therefore， this paper will review the regulatory role of PI3K/AKt signaling pathway in the prevention and treatment of hypertension ......