何国华 任小平 杨媛 贺莹 赵志娟 兀威

    【摘要】 现阶段肺癌依旧是全球发病率和死亡率排名第一的恶性肿瘤。早期诊断及治疗是提高肺癌患者生存率和预后的关键，全面地认识和掌握肺癌各种形式的临床表现是早期诊断的重要环节，尤其是以肺外症状首发的病例。本文深入分析了与肺癌相关的多种非转移性肺外表现，分别对表现于内分泌系统、神经系统、皮肤、免疫系统、眼部等的临床特征以及治疗进展等做一综述，从而减少临床漏诊、误诊率，提高临床表现不典型肺癌的早期诊断率。

    【关键词】 肺癌 早期诊断 非转移性肺外表现

    [Abstract] Lung cancer is still the leading malignancy incidence rate and mortality rate in the world. Early diagnosis and treatment is the key to improve the survival rate and prognosis of lung cancer patients. A comprehensive understanding and mastery of various forms of clinical manifestations of lung cancer is an important link in early diagnosis， especially the cases with extrapulmonary symptoms. This paper deeply analyzes a variety of non metastatic extrapulmonary manifestations related to lung cancer， and summarizes the clinical characteristics and treatment progress of endocrine system， nervous system， skin， immune system and eyes， so as to reduce the rate of clinical missed diagnosis and misdiagnosis and improve the early diagnosis rate of atypical lung cancer.

    [Key words] Lung cancer Early diagnosis Non-metastatic extrapulmonary manifestations ......