王姝涵 王岳 王玉良

    【摘要】 口腔鳞状细胞癌(oral squamous cell carcinoma，OSCC)作为常见的头颈部恶性肿瘤，死亡率较高。磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/AKT)信号通路作为分子传导机制直接参与了多种恶性肿瘤(包括OSCC)的发生发展过程。降低磷酸化PI3K和AKT的表达可以抑制OSCC细胞的进展。因此，本文对PI3K/AKT通路的组成及其对OSCC细胞周期、凋亡、自噬、侵袭与转移，糖酵解以及血管生成等的调节作用，特别是该通路作为靶向抑制剂在OSCC中的使用与发展做一总结。

    【关键词】 口腔鳞状细胞癌 磷脂酰肌醇3-激酶 蛋白激酶B

    Research Progress of PI3K/AKT Pathway in Oral Squamous Cell Carcinoma/WANG Shuhan， WANG Yue， WANG Yuliang. //Medical Innovation of China， 2022， 19(05)： -184

    [Abstract] As a common head and neck malignant tumor， oral squamous cell carcinoma (OSCC) has a high mortality rate. Phosphatidyl inositol 3 kinase/protein kinase B (PI3K/AKT) signal pathway as a molecular conduction mechanism directly involved in a variety of malignant tumors (including OSCC) development process. Decreased expression of phosphorylated PI3K and AKT could inhibit OSCC cell progression. Therefore， this article reviews the composition of PI3K/AKT pathway and its regulatory effects on OSCC cell cycle， apoptosis， autophagy， invasion and metastasis， glycolysis and angiogenesis， especially the use and development of PI3K/AKT pathway as a targeted inhibitor in OSCC ......