杨新建 戴德 罗国庆

    【摘要】 慢性炎症在喉癌发病机制中起重要作用，尤其是CD4、CD8T细胞介导的肿瘤表面抗原提呈及病变细胞清除机制。肿瘤特异性CD4T细胞能产生多种趋化因子以增强CD8T细胞的聚集、增殖和效应功能，亦可部分逆转免疫耐受，而CD4T细胞的Th17细胞和Treg细胞则介导多种肿瘤免疫抑制反应。多项研究表明，淋巴细胞数量相对减少与喉癌的不良预后和生存率相关，而较高的CD8T细胞/Treg细胞比值通常与肿瘤良好的预后相关。

    【关键词】 喉癌 免疫抑制 CD4T细胞 CD8T细胞 免疫抑制性T细胞

    Potential Association with T Lymphocytes in Laryngeal Squamous Cell Carcinoma/YANG Xinjian， DAI De， LUO Guoqing. //Medical Innovation of China， 2022， 19(05)： -188

    [Abstract] Chronic inflammation plays an essential role in the pathogenesis of laryngeal cancer， especially the mechanism of tumor surface antigen presentation mediated and the clearance of pathological cells by CD4 and CD8 T cells. Tumor-specific CD4 T cells can produce a variety of chemokines to enhance the aggregation， proliferation and effector function of CD8 T cells， and partially reverse immune tolerance， while Th17 cells and Treg cells of CD4 T cells mediate various tumor immunosuppressive responses. Several studies have shown that a relative decrease in lymphocyte count is associated with poor prognosis and survival in laryngeal cancer， while a higher CD8 T-cell/Treg ratio is generally associated with favorable tumor prognosis. ......