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    【摘要】 目的：探究染色质修饰蛋白4C(CHMP4C)对子宫颈癌的诊断價值。方法：选择2019年1-12月于锦州市中心医院接受治疗的80例病理确诊为子宫颈癌患者为研究组，另选取同期于本院接受治疗的50例良性宫颈病变患者为病例对照组，选择同期50例体格检查健康者为对照组。分别检测三组的CHMP4C蛋白、癌胚抗原(CEA)及肿瘤坏死因子α(TNF-α)水平并进行组间比较;分析CHMP4C蛋白与子宫颈癌病理特征的关系;分析CHMP4C蛋白与CEA、TNF-α水平的相关性;按照患者随访结局将80例子宫颈癌患者分为死亡组(n=21)和存活组(n=59)，对比两组患者CHMP4C、TNF-α及CEA水平差异。结果：研究组的CHMP4C蛋白、CEA、TNF-α水平均明显高于病例对照组和对照组，病例对照组的CHMP4C蛋白、CEA、TNF-α水平均明显高于对照组(P<0.05);TNM分期、肿瘤分化程度、肿瘤直径以及患者年龄均对子宫颈癌组织中CHMP4C蛋白的表达产生一定的影响(P<0.05);死亡组CHMP4C蛋白、CEA、TNF-α水平均明显高于存活组(P<0.05);CHMP4C蛋白表达与CEA、TNF-α均呈现明显的正相关性(r=0.675 6、0.920 7，P<0.05)。结论：CHMP4C蛋白与子宫颈癌患者的病理特征具有一定的相关性，可以考虑将其应用于子宫颈癌的鉴别诊断及预后分析中。

    【关键词】 CHMP4C 子宫颈癌 预后

    Diagnostic Value of Chromatin Modified Protein 4C in Cervical Cancer/CHI Xinnan. //Medical Innovation of China， 2022， 19(06)： -122

    [Abstract] Objective： To explore the diagnostic value of chromatin modified protein 4C (CHMP4C) in cervical cancer. Method： A total of 80 patients with pathological diagnosis of cervical cancer who were treated in Jinzhou Central Hospital from January to December 2019 were selected as the research group. 50 patients with benign cervical lesions who were treated in our hospital during the same period were selected as the case control group. 50 healthy patients with physical examination during the same period were selected as the control group. The CHMP4C protein ......