范苗苗 赵奇 毕佳欣 宋洁 赵若晗

    【摘要】 乳腺癌是一种具有复杂异质性的恶性肿瘤，其发生发展与多种因素密切相关。尽管乳腺癌的诊断和治疗水平有明显提高，但它仍然是女性肿瘤死亡的第二大原因。因此，探知新的乳腺癌生物标志物和新的治疗靶标具有重要价值。基因表达的任一环节出现异常都有可能导致癌症的发生，竞争性内源性RNA假说认为不同非编码RNA之间通过作用于相同的微小RNA反应元件来调节基因的表达。本文主要对不同类的非编码RNA在乳腺癌中的研究进展进行综述，同时汇总文献已报道的非编码在乳腺癌中作为竞争性内源性RNA调控的研究结果，为精确治疗靶标提供理论基础。

    【关键词】 乳腺癌 竞争性内源RNA 微小RNA 环状RNA 长链非编码RNA

    Research Progress of Non-coding RNA in Breast Cancer/FAN Miaomiao， ZHAO Qi， BI Jiaxin， SONG Jie， ZHAO Ruohan. //Medical Innovation of China， 2022， 19(17)： -183

    [Abstract] Breast cancer is a malignant tumor with complex heterogeneity， and its occurrence and development are closely related to many factors. Despite significant improvements in diagnosis and treatment of breast cancer， it remains the second leading cause of cancer death in women. Therefore， it is of great value to explore new biomarkers and therapeutic targets for breast cancer. Any abnormality of each phase in gene expression can lead to cancer. Competing endogenous RNA hypothesis suggestes that different non-coding RNA regulate gene expression by acting on the same miRNA response elements. This paper mainly reviews the research progress of different classes of non-coding RNA in breast cancer ......