束宁德 赵洋 刘庆新

    【摘要】 椎基底动脉延长扩张症(vertebrobasilar dolichoectasia，VBD)是腦血管病的一种，主要表现为椎动脉和/或基底动脉的异常扩张迂曲，属于向外的营养不良重构。由于椎基底动脉所处位置空间狭小，供血区包含多个重要中枢，其过度迂曲扩张将产生较为严重的后果。目前关于VBD病因的研究较少，近期的研究结果表明炎症、血流动力学等参与了VBD病变血管重构，进一步导致VBD的发生发展。本文现围绕VBD血管重构相关病因的研究进展进行综述，以期为VBD发生发展机制方面的研究提供新思路并为相关治疗研究提供新方向。

    【关键词】 椎基底动脉延长扩张症 血管重构 病因

    Research Progress on Etiology of Vascular Remodeling in Vertebrobasilar Dolichoectasia/SHU Ningde， ZHAO Yang， LIU Qingxin. //Medical Innovation of China， 2022， 19(18)： -176

    [Abstract] Vertebrobasilar dolichoectasia (VBD) is a kind of cerebrovascular disease， mainly manifested as abnormal dilation and tortuality of vertebral artery and/or basilar artery， which belongs to outward hypotrophic remodeling. Due to the narrow location of vertebrobasilar artery， the blood supply area contains several important centers， and its excessive tortuous expansion will produce serious consequences. Currently， there are few studies on the etiology of VBD. Recent research results indicate that inflammation and hemodynamics， for example， are involved in vascular remodeling in VBD， further leading to the occurrence and development of VBD. This paper reviews the research progress on the etiology of vascular remodeling in VBD ......