崔博

    【摘要】 目的：探讨替莫唑胺联合显微镜下经鼻蝶窦垂体瘤切除术治疗垂体瘤的效果。方法：选取2020年4月-2022年4月佳木斯市中心医院收治的102例垂体瘤患者为对象，随机分为对照组、观察组，各51例。对照组给予显微镜下经鼻蝶窦垂体瘤切除术治疗，观察组在对照组基础上增加替莫唑胺治疗。综合评估两组临床疗效、激素水平、炎症因子水平、生活质量、治疗安全性。結果：观察组总有效率为92.16%，高于对照组的74.51%(P0.05)。结论：替莫唑胺联合显微镜下经鼻蝶窦垂体瘤切除术治疗垂体瘤效果显著，可抑制患者激素和炎症因子的表达，改善患者生活质量，治疗安全性良好。

    【关键词】 垂体瘤 显微镜下经鼻蝶窦垂体瘤切除术 替莫唑胺 激素水平 炎症因子

    Analysis of the Effect of Temozolomide Combined with Microscopical Transsphenoidal Pituitary Tumor Resection in the Treatment of Pituitary Tumor/CUI Bo. //Medical Innovation of China， 2023， 20(12)： 0-038

    [Abstract] Objective： To investigate the effect of Temozolomide combined with microscopical transsphenoidal pituitary tumor resection in the treatment of pituitary tumor. Method： A total of 102 patients with pituitary tumor who were admitted to Jiamusi Central Hospital from April 2020 to April 2022 were selected and randomly divided into a control group and an observation group ......