张昱 张金卓

    【摘要】 结直肠癌是我国最常见的恶性肿瘤之一，随着社会发展，人们生活水平逐渐提高，结直肠癌的发病率及死亡率在近几年也呈现快速增长趋势。由于结直肠癌的演变是一种慢性发生发展过程，临床上可通过早期筛查检出病变并及时治疗，从而显著降低其发病率和死亡率。目前常用检测方法包括风险评估问卷、粪便潜血试验(FOBT)、血清肿瘤标志物检测、血清或粪便DNA甲基化检测、结肠镜检查等。本文旨在对现有的常用结直肠癌早期筛查方法及检测生物标志物相关研究进行综述，以期为临床结直肠癌早期筛查及诊断提供一定价值的参考。

    【关键词】 结直肠癌 早期筛查 DNA甲基化 基因检测

    Advances in Early Screening and Diagnostic Biomarkers of Colorectal Cancer/ZHANG Yu， ZHANG Jinzhuo. //Medical Innovation of China， 2023， 20(12)： -173

    [Abstract] Colorectal cancer is one of the most common malignant tumors in China， with the development of society and the gradual improvement of people's living standards， the incidence and mortality of colorectal cancer have also shown a rapid growth trend in recent years. Since the evolution of colorectal cancer is a chronic process of occurrence and development， early detection of lesions and timely treatment can significantly reduce its morbidity and mortality. At present， common detection methods include risk assessment questionnaire， fecal occult blood test (FOBT)， serum tumor marker detection， serum or fecal DNA methylation detection ......