【摘要】 外泌体是一种由脂膜包被的、由大多数活细胞分泌的囊泡小体，携带有大量的miRNA和其他的核酸、蛋白等物质。外泌体中的内含物能够用于肺癌的诊断，且与肺癌细胞的生物学功能有关。在肺癌的发生发展过程中，癌细胞来源的外泌体既能够直接影响癌细胞的生物学功能，也能够通过影响巨噬细胞、成纤维细胞、内皮细胞等其他细胞，进而间接促进肿瘤生长。了解外泌体与肺癌细胞的分子机制能够为肺癌的早期诊断与精准治疗提供新的契机，有望使其成为肺癌诊断的有效标志物和治疗的潜在靶点。本文就目前外泌体在肺癌中的相关研究进程展开综述。

    【关键词】 外泌体 肺癌 生物标志物

    Research Status and Progress of Exosomes in the Non-small Cell Lung Cancer/QIN E. //Medical Innovation of China， 2023， 20(34)： -188

    [Abstract] Exosomes are vesicle bodies surrounded by lipid membranes and secreted by most cells， carrying a large number of miRNA and other nucleic acids， proteins and other substances. Many studies have confirmed that exosome inclusions are related to the diagnosis of lung cancer and biological function of lung cancer cells. During the development of lung cancer， exosomes derived from cancer cells could not only directly affect the biological function of cancer cells， but indirectly promote tumor growth by affecting macrophages， fibroblasts， endothelial cells and other cells. Understanding the molecular mechanism of exosomes and lung cancer cells can provide a new opportunity for early diagnosis and precise treatment of lung cancer ......