毛曼姿 蔡华 陈智远

    【摘要】 慢性疾病逐渐成为我国居民死亡的首位原因，给社会造成巨大的负担。饮食控制是对慢性疾病管理的重要方式。隔日禁食(alternate-day fasting，ADF)是一种禁食日与自由进食日交替进行的新兴饮食模式。此综述通过分析隔日禁食在慢性疾病的文献，发现隔日禁食在预防和改善神经系统疾病、心血管疾病、肿瘤、代谢性疾病等方面有着积极影响。目前隔日禁食的研究仍是在动物方面较多，广泛的推广需更多的临床随机试验，评估其安全性、有效性和依从性。

    【关键词】 隔日禁食 慢性疾病 神经系统疾病 心血管疾病 肿瘤 代谢性疾病

    [Abstract] Chronic diseases have gradually become the first cause of death in our country， causing huge social burden. Diet control is an important way for the management of chronic diseases. Alternate-day fasting (ADF) is a new dietary pattern that alternates between fasting days with free-eating days. This review analyzes the literature on alternate-day fasting in chronic diseases， and finds that alternate-day fasting has a positive effect on the prevention and improvement of neurological disorder diseases， cardiovascular diseases， cancers， metabolic diseases and so on. At present， the study of alternate-day fasting is still more in animals， and more clinical randomized trials are need to evaluate its safety， effectiveness， and compliance.

    [Key words] Alternate-day fasting Chronic disease Neurological disorder disease Cardiovascular disease Tumour Metabolic disease ......