李晓岚 黄建敏

    【摘要】 小窝蛋白1(caveolin-1，Cav-1)是小窝中的一种支架蛋白和胆固醇结合蛋白，是细胞膜穴样内陷的主要结构成分，在脂质转运、细胞生长分化、血管生成等方面有着重要的作用。Cav-1在中枢神经系统的内皮细胞、周细胞、星形胶质细胞等许多细胞中表达。现有研究表明Cav-1与多种中枢神经系统疾病之间存在密切联系，本文简要概述Cav-1与脑梗死的关系。

    【关键词】 小窝蛋白1 脑梗死 动脉粥样硬化 血管生成

    Research Progress in the Correlation between Caveolin-1 and Cerebral Infarction/LI Xiaolan， HUANG Jianmin. //Medical Innovation of China， 2024， 21(05)： -179

    [Abstract] Caveolin-1 (Cav-1) is a scaffold protein and cholesterol binding protein in caveolae. It is the main structural component of cell membrane hole-like invagination， and plays an important role in lipid transport， cell growth and differentiation， angiogenesis and other aspects. Cav-1 is expressed in many other cells， including endothelial cells， pericytes， and astrocytes of the central nervous system. Existing studies indicate a close link between Cav-1 and multiple central nervous system diseases， which provide a brief overview of the relationship between Cav-1 and cerebral infarction.

    [Key words] Caveolin-1 Cerebral infarction Atherosclerosis Angiogenesis

    腦梗死是严重危害人类健康的常见疾病，其发生发展是一个包含动脉粥样硬化、神经炎症、神经功能修复等在内的复杂病理生理过程 ......