赵博慧 孙云晖

    【摘要】 白细胞介素38(interleukin-38，IL-38)是IL-1家族的最新成员，在健康者及患者血清中均可表达。它可以通过结合相关受体，调节信号通路发挥其对炎症细胞因子的产生以及功能的调节作用。近年来研究发现IL-38在肿瘤、免疫性疾病、消化系病及心血管疾病等疾病中发挥重要作用，研究证实IL-38在慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD)、支气管哮喘、肺癌、肺纤维化等呼吸系统疾病的发生发展过程中同样扮演着炎症调节的重要角色。

    【关键词】 白细胞介素38 呼吸系统疾病 炎症因子

    Research Progress on the Relationship between IL-38 and Respiratory Diseases/ZHAO Bohui， SUN Yunhui. //Medical Innovation of China， 2024， 21(07)： -159

    [Abstract] Interleukin 38 (IL-38) is the newest member of the IL-1 family， which can be expressed in the serum of both healthy people and patients. It can regulate the production and function of inflammatory cytokines by binding to related receptors and inhibiting signal pathways. In recent years， studies have found that IL-38 plays an important role in tumors， immune diseases， digestive diseases and cardiovascular diseases. Studies have confirmed that IL-38 also plays an important role in regulating inflammation in the occurrence and development of respiratory diseases such as chronic obstructive pulmonary disease (COPD)， bronchial asthma ......