肝星状细胞的激活与凋亡相关信号通路研究进展(4)
[17]Tsukada S,Westwick JK,Ikejima K,etal.SMAD and p38 MAPK signaling pathways independently regulate α1(I)collagen gene expression in unstimulated hepatic stellate cells.J Biol Chem，2005，2806(20):10055-10064.
[18]Furukawa F,Matsuzaki K,Mori S,et al.P38MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts.Hepatology, 2003,38(4):879-889.
[19]Varela-Rey M,Montiel-Duarte C,Oses-Prieto JA,et al.P38MAPK mediates the regulation of alphal(I) procolla- gene mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells.FEBS Lett,2002,528(1-3):133-138.
, 百拇医药
[20]Schnabl B,Bradham CA,Bennett BL,et al.TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.Hepatology,2001,34(5):953-963.
[21]Yoshida K,Matsuzaki K,Mori S,et al.Transforming growth factor-beta and platelet-derived growth factor signal via c-jun N-terminal kinase-dependeant Smad2/3 phosphorylation in rat hepatic sellate cells after acute liver injury.Am J Pathol，2005,(166):1029-1039.
[22]Li J,HuW,Baldassare JJ,et al.The ethanol metabolite, linolenic acid ethyl ester,stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells.Life Sci,2003,73(9):1083-1096.
, 百拇医药
[23]Pinzani M.PDGF and signal transduction in hepatic stellate cells.Front Bio sci,2002,7:d1720-d1726.
[24]Adachi T,Togashi H,Suzuki A,et al.NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells.Hepatology,2005,41(6):1272-1281.
[25]Gabele E,Reif S,Tsukada S,et al.The role of p70s6k in hepatic stellate cell collagen gene expression and cell proliferation.J Biol Chem.2005,280(4):13374-13382.
, 百拇医药
[26]Saxena NK,Ikeda K,Rockey DC,et al.Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob ice.Hepatology,2002,35(4):762-771.
[27]Cao Q,Mak KM,Lieber CS,et al.Leptin enhances α1(I)colllagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways.J Cell Biochem.2006,97(1):188-197.
[28]Saxena NK,Titus MA,Ding X,etal.Leptin as a novel profibrogenic cytokine in hepatic stellate cells:mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase(Erk) and Akt phosphorylation.FASEB J.2004,18(13):1612-1614.
, 百拇医药
[29]Novitskiy G,Ravi R,Potter JJ,et al.Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells.Alcohol，2005,40(2):96-101.
[30]Gao R,Brigstock DR.Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor(CCN2) is involved in sustaining the survivalofprimary rathepatic stellate cells.Cell Commun Signa,2005,3:14.
[31]Yang L,Chan CC,Kwon 0S,et al.Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.Am J Physiol Gastrointest Liver Physiol，2006，291:902-911.
[32]Galli A,Crabb D,Price D,et al.Peroxisome proliferator activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation ofhuman hepatic stellate cells.Hepatology,2000,31(1):101-108., 百拇医药(尤俊勇 王效民)
[18]Furukawa F,Matsuzaki K,Mori S,et al.P38MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts.Hepatology, 2003,38(4):879-889.
[19]Varela-Rey M,Montiel-Duarte C,Oses-Prieto JA,et al.P38MAPK mediates the regulation of alphal(I) procolla- gene mRNA levels by TNF-alpha and TGF-beta in a cell line of rat hepatic stellate cells.FEBS Lett,2002,528(1-3):133-138.
, 百拇医药
[20]Schnabl B,Bradham CA,Bennett BL,et al.TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.Hepatology,2001,34(5):953-963.
[21]Yoshida K,Matsuzaki K,Mori S,et al.Transforming growth factor-beta and platelet-derived growth factor signal via c-jun N-terminal kinase-dependeant Smad2/3 phosphorylation in rat hepatic sellate cells after acute liver injury.Am J Pathol，2005,(166):1029-1039.
[22]Li J,HuW,Baldassare JJ,et al.The ethanol metabolite, linolenic acid ethyl ester,stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cells.Life Sci,2003,73(9):1083-1096.
, 百拇医药
[23]Pinzani M.PDGF and signal transduction in hepatic stellate cells.Front Bio sci,2002,7:d1720-d1726.
[24]Adachi T,Togashi H,Suzuki A,et al.NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells.Hepatology,2005,41(6):1272-1281.
[25]Gabele E,Reif S,Tsukada S,et al.The role of p70s6k in hepatic stellate cell collagen gene expression and cell proliferation.J Biol Chem.2005,280(4):13374-13382.
, 百拇医药
[26]Saxena NK,Ikeda K,Rockey DC,et al.Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob ice.Hepatology,2002,35(4):762-771.
[27]Cao Q,Mak KM,Lieber CS,et al.Leptin enhances α1(I)colllagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H2O2-dependent MAPK pathways.J Cell Biochem.2006,97(1):188-197.
[28]Saxena NK,Titus MA,Ding X,etal.Leptin as a novel profibrogenic cytokine in hepatic stellate cells:mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase(Erk) and Akt phosphorylation.FASEB J.2004,18(13):1612-1614.
, 百拇医药
[29]Novitskiy G,Ravi R,Potter JJ,et al.Effects of acetaldehyde and TNF alpha on the inhibitory kappa B-alpha protein and nuclear factor kappa B activation in hepatic stellate cells.Alcohol，2005,40(2):96-101.
[30]Gao R,Brigstock DR.Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor(CCN2) is involved in sustaining the survivalofprimary rathepatic stellate cells.Cell Commun Signa,2005,3:14.
[31]Yang L,Chan CC,Kwon 0S,et al.Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis.Am J Physiol Gastrointest Liver Physiol，2006，291:902-911.
[32]Galli A,Crabb D,Price D,et al.Peroxisome proliferator activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation ofhuman hepatic stellate cells.Hepatology,2000,31(1):101-108., 百拇医药(尤俊勇 王效民)