地中海贫血患儿群体反应性抗体对脐血CD34+细胞集落形成的影响(1)
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【摘要】目的探讨特异性群体反应性抗体(Panel Reactive Antibody,PRA)对脐血CD34+细胞集落形成的影响。方法取含PRA的β地贫患儿血清，与脐血CD34+细胞、补体联合孵育，行半固体集落培养，观察其对CD34+细胞集落形成影响。结果经PRA阳性血清孵育的脐血CD34+细胞经半固体集落培养所形成的集落数下降。结论地中海贫血血清PRA对脐血CD34+细胞的集落形成能力有抑制作用，补体可增强上述作用。
【关键词】脐血；CD34+造血干细胞；地中海贫血；群体反应性抗体
The effect of thalassemia PRA on the colony formation of CD34+ cells from cord blood YANG Xing-ge,MA Guo-rui,LU Xue-liang.First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China.
【Abstract】ObjectiveTo explore the effect of thalassemia PRA on the colony formation of CD34+ cells from cord blood.MethodsThe PRA sera from patients with β-thalassemia,CD34+ cells of umbilical cord blood were incubated with different sera and complement respectively.ResultsAfter the PRA serum incubation the counts of the colony formation of CD34+ cells from cord blood were decreased ......
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