D—二聚体升高的临床意义与骨折关系分析(2)
总之血浆D-二聚体作为一项辅助指标,具有检测方便、快速、经济的优势,可用作骨折术前、术后血栓风险的预测、静脉血栓栓塞症的筛查等。尽管其在临床应用中特异性很低,但它具有很高的敏感性和阴性预测值。那么,如何制定合适的临界值来提高D-二聚体在相关疾病中的灵敏度和阴性预测值则是在实践中需要探索的一个新问题还有待深入地探究。
参考文献
[1]张燕,胡进林,刘地发,等.恶性肿瘤患者血浆D-二聚体测定及临床意义[J].基层医学论坛,2006,10(12):1097.
[2]Wada H,Sase T,Ymaguchi M.Hypercoagulant states in malignant lymphoma[J].Exponcol,2005,27(3):179-180.
[3]周贞.D-二聚体检测在妇科恶性肿瘤中的临床意义[J].中国卫生检验杂志,2010,20(5):1141-1142.
[4]Owings J T,Gosselin R C,Andeson J T,et al.Practical utility of the D-dimer assay for excluding thromboenbolism in severely injured trauma patients[J].Trauma,2001,51(2):425-430.
[5]马海梅,张会英,张力丹,等.1334例创伤骨科患者血浆D-二聚体水平的回顾分析[J].血栓与止血学,2009,15(5):225-227.
[6]Gambhir R P.Another nail in the coffin for role of D-dimer in diagnosis of postoperative deep vein thrombosis[J].Ann R Coll Surg Engl,2009,91(3):355.
[7]王海,赵宝林,齐新,等.老年下肢骨折病人D-二聚体定量检测的临床价值[J].吉林医学,2006,27(7):746-747.
[8]Dindo D,Breitenstein S,Hahnloser D,et al.Kinetics of D-dimer after general surgery[J].Blood Coagul Fibrinolysis,2009,20(2):347-352.
[9]黄永祥.浅谈D-二聚体检测的临床意义[J].中国医学创新,2011,8(12):175-176.
(收稿日期:2013-05-17) (编辑:程旭然), 百拇医药(戴宏华)
参考文献
[1]张燕,胡进林,刘地发,等.恶性肿瘤患者血浆D-二聚体测定及临床意义[J].基层医学论坛,2006,10(12):1097.
[2]Wada H,Sase T,Ymaguchi M.Hypercoagulant states in malignant lymphoma[J].Exponcol,2005,27(3):179-180.
[3]周贞.D-二聚体检测在妇科恶性肿瘤中的临床意义[J].中国卫生检验杂志,2010,20(5):1141-1142.
[4]Owings J T,Gosselin R C,Andeson J T,et al.Practical utility of the D-dimer assay for excluding thromboenbolism in severely injured trauma patients[J].Trauma,2001,51(2):425-430.
[5]马海梅,张会英,张力丹,等.1334例创伤骨科患者血浆D-二聚体水平的回顾分析[J].血栓与止血学,2009,15(5):225-227.
[6]Gambhir R P.Another nail in the coffin for role of D-dimer in diagnosis of postoperative deep vein thrombosis[J].Ann R Coll Surg Engl,2009,91(3):355.
[7]王海,赵宝林,齐新,等.老年下肢骨折病人D-二聚体定量检测的临床价值[J].吉林医学,2006,27(7):746-747.
[8]Dindo D,Breitenstein S,Hahnloser D,et al.Kinetics of D-dimer after general surgery[J].Blood Coagul Fibrinolysis,2009,20(2):347-352.
[9]黄永祥.浅谈D-二聚体检测的临床意义[J].中国医学创新,2011,8(12):175-176.
(收稿日期:2013-05-17) (编辑:程旭然), 百拇医药(戴宏华)