胰岛素泵和多次胰岛素强化治疗初发2型糖尿病的临床对比(1)
【摘要】 目的：探讨胰岛素泵和多次胰岛素强化治疗初发2型糖尿病的临床效果。方法：选取笔者所在医院2013年3月-2015年3月收治的86例初发2型糖尿病患者作为研究对象，随机分成对照组与观察组，每组43例，对照组使用多次胰岛素强化治疗，观察组使用胰岛素泵治疗，比较分析两组患者治疗后血糖控制情况、低血糖发生率。结果：两组患者治疗后都能较好地控制空腹血糖、餐后2 h血糖及糖化血红蛋白水平，但观察组患者餐后2 h血糖与空腹血糖控制效果更显著，差异均有统计学意义(P<0.05)；观察组低血糖发生率为4.65%，明显低于对照组的20.93%，差异有统计学意义(P<0.05)；观察组患者胰岛素用量、血糖达标时间明显低于对照组，差异有统计学意义(P<0.05)。结论：胰岛素泵和多次胰岛素强化治疗均能控制初发2型糖尿病患者血糖浓度，但胰岛素泵治疗方法可降低低血糖发生率，缩短血糖达标时间，值得临床推广应用。
【关键词】 胰岛素泵； 多次胰岛素； 强化治疗； 初发2型糖尿病
, 百拇医药 doi：10.14033/j.cnki.cfmr.2017.4.058 文献标识码 B 文章编号 1674-6805(2017)04-0108-02
【Abstract】 Objective：To investigate the clinical effect of insulin pump and multiple insulin intensive treatment on type 2 diabetes mellitus.Method：86 cases of incipient type 2 diabetic patients in the author’s hospital from March 2013 to March 2015 were selected as the research object，randomly divided into control group and observation group，with 43 cases in each group，the control group was treated with repeatedly intensive insulin therapy，the observation group was treated with insulin pump therapy.The control situation of blood glucose and the hypoglycemia incidence of the patients in two groups were compared.Result：After treatment，the control of fasting blood glucose，2-hour post-meal blood glucose and glycosylated hemoglobin level of two groups were better than prior treatment，but the fasting blood glucose，2-hour post-meal blood glucose of observing group were more effective，the difference was statistically significant(P<0.05).The hypoglycemia risk of observation group was 4.65%，significantly lower than 20.93% of control group，the difference was statistically significant(P<0.05).The insulin dosage and blood glucose control time of observation group were significantly lower than that of the control group，the difference was statistically significant(P<0.05).Conclusion：Insulin pump and multiple intensive insulin therapy both can control of blood glucose levels in patients with type 2 diabetes，but insulin pump treatment can reduce the incidence of hypoglycemia，shorten the time of blood glucose，worthy of clinical application.
, http://www.100md.com
【Key words】 Insulin pump； Multiple insulin； Intensive therapy； Early type 2 diabetes mellitus
First-author’s address：Center Health Center of Liuzhou City，Liuzhou 545003，China
隨着社会经济的发展，人们生活水平日益提高，糖尿病发生率也逐渐升高，严重影响患者的生活质量。2型糖尿病主要是各种代谢因素对血液结构平衡的破坏，导致血液中胰岛素效力减弱，进而使患者体内胰岛素处于比较缺乏状态，导致血糖升高[1]。本次研究将重点探讨比较胰岛素泵和多次胰岛素强化治疗初发2型糖尿病的临床效果，详情如下。
1 资料与方法
1.1 一般资料
选取笔者所在医院2013年3月-2015年3月收治的初发2型糖尿病患者86例作为试验对象，所选患者均符合WHO的2型糖尿病诊断及分型标准，且所有患者均未使用过胰岛素或口服降糖药，且排除以下患者：合并心肝肾功能不全者；患有严重感染、酮症酸中毒患者。按照随机数表法将两组患者平均分为观察组和对照组，各43例。观察组中男20例，女23例，年龄36～79岁，病程7个月～3年；对照组中男22例，女21例，年龄37～77岁，病程5个月～3年。两组患者一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张荣彦)
【关键词】 胰岛素泵； 多次胰岛素； 强化治疗； 初发2型糖尿病
, 百拇医药 doi：10.14033/j.cnki.cfmr.2017.4.058 文献标识码 B 文章编号 1674-6805(2017)04-0108-02
【Abstract】 Objective：To investigate the clinical effect of insulin pump and multiple insulin intensive treatment on type 2 diabetes mellitus.Method：86 cases of incipient type 2 diabetic patients in the author’s hospital from March 2013 to March 2015 were selected as the research object，randomly divided into control group and observation group，with 43 cases in each group，the control group was treated with repeatedly intensive insulin therapy，the observation group was treated with insulin pump therapy.The control situation of blood glucose and the hypoglycemia incidence of the patients in two groups were compared.Result：After treatment，the control of fasting blood glucose，2-hour post-meal blood glucose and glycosylated hemoglobin level of two groups were better than prior treatment，but the fasting blood glucose，2-hour post-meal blood glucose of observing group were more effective，the difference was statistically significant(P<0.05).The hypoglycemia risk of observation group was 4.65%，significantly lower than 20.93% of control group，the difference was statistically significant(P<0.05).The insulin dosage and blood glucose control time of observation group were significantly lower than that of the control group，the difference was statistically significant(P<0.05).Conclusion：Insulin pump and multiple intensive insulin therapy both can control of blood glucose levels in patients with type 2 diabetes，but insulin pump treatment can reduce the incidence of hypoglycemia，shorten the time of blood glucose，worthy of clinical application.
, http://www.100md.com
【Key words】 Insulin pump； Multiple insulin； Intensive therapy； Early type 2 diabetes mellitus
First-author’s address：Center Health Center of Liuzhou City，Liuzhou 545003，China
隨着社会经济的发展，人们生活水平日益提高，糖尿病发生率也逐渐升高，严重影响患者的生活质量。2型糖尿病主要是各种代谢因素对血液结构平衡的破坏，导致血液中胰岛素效力减弱，进而使患者体内胰岛素处于比较缺乏状态，导致血糖升高[1]。本次研究将重点探讨比较胰岛素泵和多次胰岛素强化治疗初发2型糖尿病的临床效果，详情如下。
1 资料与方法
1.1 一般资料
选取笔者所在医院2013年3月-2015年3月收治的初发2型糖尿病患者86例作为试验对象，所选患者均符合WHO的2型糖尿病诊断及分型标准，且所有患者均未使用过胰岛素或口服降糖药，且排除以下患者：合并心肝肾功能不全者；患有严重感染、酮症酸中毒患者。按照随机数表法将两组患者平均分为观察组和对照组，各43例。观察组中男20例，女23例，年龄36～79岁，病程7个月～3年；对照组中男22例，女21例，年龄37～77岁，病程5个月～3年。两组患者一般资料比较差异无统计学意义(P>0.05)，具有可比性。, http://www.100md.com(张荣彦)