and urinary Ca/Cr (0.13±0.06) in the observation group were lower than those in the control group，the differences were statistically significant(P<0.05).The incidence of osteoporosis in the observation group was 3.33% after 12 months of treatment，which was lower than 20.00% in the control group，the difference was statistically significant(P<0.05).Conclusion：For patients with lupus nephritis，long-term application of low-dose glucocorticoids can reduce bone mineral density and increase the probability of osteoporosis ......