持续呼吸道正压通气与双水平正压通气在早产儿呼吸窘迫综合征中的对比应用研究(1)
【摘要】 目的：對比分析持续呼吸道正压通气与双水平正压通气在早产儿呼吸窘迫综合征中的治疗效果。方法：选取医院内部2016年10月-2019年3月收治的45例早产儿呼吸窘迫综合征患儿进行研究，采用随机数字表法将入组患儿分成研究组23例和对照组22例，分别实施双水平正压通气治疗(BiPAP)和持续呼吸道正压通气治疗(CPAP)，对比两组通气参数、血气分析指标及治疗后并发症发生情况。结果：通气治疗开始前两组PEEP、FiO2、PaCO2水平比较，差异均无统计学意义(P>0.05)。通气治疗12、48 h后，研究组PEEP、FiO2、PaCO2水平均明显低于对照组，差异均有统计学意义(P<0.05)。研究组并发症发生率为30.43%，显著低于对照组的68.18%，差异有统计学意义(P<0.05)。结论：在早产儿呼吸窘迫综合征治疗中，在常规治疗基础上合理使用BiPAP治疗方法，能够使患儿的通气和血气指标得到及时有效的改善，且能够显著降低患儿出现并发症的风险，有助于降低气管插管率，适宜在临床治疗中推广应用。
【关键词】 双水平正压通气; 持续呼吸道正压通气; 早产儿; 呼吸窘迫综合征; 治疗效果; 气管插管率
doi：10.14033/j.cnki.cfmr.2019.24.066 文献标识码 B 文章编号 1674-6805(2019)24-0-03
【Abstract】 Objective：To compare and analyze the therapeutic effect of continuous positive airway pressure ventilation and Bi-level positive airway pressure ventilation in premature infants with respiratory distress syndrome.Method：A total of 45 cases of respiratory distress syndrome of premature infants admitted to our hospital from October 2016 to March 2019 were selected for this study.The children were divided into 23 cases in the study group and 22 cases in the control group by random number table.BiPAP and CPAP were applied respectively.Ventilation parameters and blood gas analysis indicators，as well as complications after treatment were compared between the two groups.Result：PEEP，FiO2 and PaCO2 levels were compared in the two groups at the beginning of ventilation therapy，the differences were not statistically significant(P>0.05).After 12 and 48 hours of ventilation therapy，the levels of PEEP，FiO2 and PaCO2 in the study group were significantly lower than those of the control group，and the differences were statistically significant(P<0.05).The incidence of complications in the study group was 30.43%，which was significantly lower than that of the control group(68.18%)，the difference was statistically significant(P<0.05).Conclusion：In the treatment of respiratory distress syndrome in premature infants，rational use of BiPAP on the basis of routine treatment can improve the ventilation and blood gas indexes of children in a timely and effective，and can significantly reduce the risk of complications in children，help to reduce the endotracheal intubation rate，and is suitable for clinical application.
【Key words】 Bi-level positive airway pressure ventilation; Continuous positive airway pressure ventilation; Premature infant; Respiratory distress syndrome; Therapeutic effect; Endotracheal intubation rate
First-author’s address：Donghai County People’s Hospital，Donghai 222300，China, http://www.100md.com(郭静)
【关键词】 双水平正压通气; 持续呼吸道正压通气; 早产儿; 呼吸窘迫综合征; 治疗效果; 气管插管率
doi：10.14033/j.cnki.cfmr.2019.24.066 文献标识码 B 文章编号 1674-6805(2019)24-0-03
【Abstract】 Objective：To compare and analyze the therapeutic effect of continuous positive airway pressure ventilation and Bi-level positive airway pressure ventilation in premature infants with respiratory distress syndrome.Method：A total of 45 cases of respiratory distress syndrome of premature infants admitted to our hospital from October 2016 to March 2019 were selected for this study.The children were divided into 23 cases in the study group and 22 cases in the control group by random number table.BiPAP and CPAP were applied respectively.Ventilation parameters and blood gas analysis indicators，as well as complications after treatment were compared between the two groups.Result：PEEP，FiO2 and PaCO2 levels were compared in the two groups at the beginning of ventilation therapy，the differences were not statistically significant(P>0.05).After 12 and 48 hours of ventilation therapy，the levels of PEEP，FiO2 and PaCO2 in the study group were significantly lower than those of the control group，and the differences were statistically significant(P<0.05).The incidence of complications in the study group was 30.43%，which was significantly lower than that of the control group(68.18%)，the difference was statistically significant(P<0.05).Conclusion：In the treatment of respiratory distress syndrome in premature infants，rational use of BiPAP on the basis of routine treatment can improve the ventilation and blood gas indexes of children in a timely and effective，and can significantly reduce the risk of complications in children，help to reduce the endotracheal intubation rate，and is suitable for clinical application.
【Key words】 Bi-level positive airway pressure ventilation; Continuous positive airway pressure ventilation; Premature infant; Respiratory distress syndrome; Therapeutic effect; Endotracheal intubation rate
First-author’s address：Donghai County People’s Hospital，Donghai 222300，China, http://www.100md.com(郭静)