【摘要】 目的：探讨益生菌联合四联方案治疗十二指肠球部溃疡伴有幽门螺杆菌感染的临床效果及不良反应。方法：选择2018年2月-2019年2月来笔者所在医院消化内科就诊的124例十二指肠球部溃疡伴有幽门螺杆菌感染患者作为研究对象。将入组对象采用随机数字表法分为观察组(益生菌联合四联方案)和对照组(四联方案)，每组62例。比较两组溃疡愈合率、幽门螺杆菌根除率和不良反应发生率。结果：观察组十二指肠球部溃疡愈合率、幽门螺杆菌根除率均高于对照组，差异均有统计学意义(P<0.05)。观察组腹泻和腹胀发生率均低于对照组，差异均有统计学意义(P<0.05)，两组皮疹、味觉异常和厌食发生率对比差异无统计学意义(P>0.05)。结论：益生菌联合四联方案不仅能显著提高十二指肠球部溃疡愈合率和幽门螺杆菌根除率，还能够显著降低四联方案的胃肠道不良反应，值得临床推广。

    【关键词】 益生菌 四联方案 幽门螺杆菌 十二指肠球部溃疡 不良反应

    [Abstract] Objective： To explore the clinical effects and adverse reactions of probiotics combined with quadruple regimen in treatment of duodenal ulcer with Helicobacter pylori infection. Method： A total of 124 patients with duodenal bulb ulcer with Helicobacter pylori infection in our hospital from February 2018 to February 2019 were enrolled. The enrolled subjects were divided into the observation group (probiotic combined with quadruple protocol) and the control group (quadruple protocol) by random number table method ......