应用血流介导的血管舒张反应评价美沙酮维持治疗者血管内皮功能(1)
【摘要】 目的：應用血流介导的血管舒张反应评价美沙酮维持治疗者的血管内皮功能。方法：选取2017年1月-2018年12月在本区各医疗机构收治的52例吸毒者为研究对象，其中24例美沙酮门诊初诊者为美沙酮初诊组，28例美沙酮维持治疗者为美沙酮维持治疗组，同时选取30例健康志愿者作为正常对照组。比较三组肱动脉基础内径、肱动脉反应性充血内径、肱动脉基础血流速度、减压后肱动脉最大血流速度、肱动脉血流介导的内径扩张值。结果：美沙酮维持治疗组及美沙酮初诊组肱动脉基础内径均大于正常对照组，且美沙酮初诊组大于美沙酮维持治疗组，差异有统计学意义(P<0.05)。美沙酮初诊组、美沙酮维持治疗组肱动脉血流介导内径扩张值明显低于正常对照组，且美沙酮初诊组低于美沙酮维持治疗组，差异有统计学意义(P<0.05)。美沙酮初诊组肱动脉基础血流速度明显高于美沙酮维持治疗组及正常对照组，差异有统计学意义(P<0.05)。三组肱动脉反应性充血内径、减压后肱动脉最大血流速度比较差异均无统计学意义(P>0.05)结论：可利用FMD技术长期随访美沙酮维持治疗患者的血管内皮功能，根据FMD结果评价美沙酮维持治疗的效果，建议在临床中广泛应用。
【关键词】 血流介导的血管舒张反应 美沙酮维持治疗 血管内皮功能 评估价值
doi：10.14033/j.cnki.cfmr.2020.12.011 文献标识码 B 文章编号 1674-6805(2020)12-00-03
Evaluation of Vascular Endothelial Function in Patients with Methadone Maintenance Treatment Using Blood Flow-mediated Vasodilation Response/ZHONG Min， PENG Yunrong， XIAO Min， LUO Yanping， LUO Lin， FAN Guoyu， LU Kun， LI Ming. //Chinese and Foreign Medical Research， 2020， 18(12)： -28
[Abstract] Objective： To evaluate the vascular endothelial function in patients with Methadone maintenance treatment by blood flow-mediated vasodilation. Method： A total of 52 drug abusers admitted in various medical institutions in this district from January 2017 to December 2018 were selected as the research objects. Among them， 24 cases with Methadone initial diagnosis were in the Methadone initial diagnosis group， and 28 cases with Methadone maintenance treatment were in the Methadone maintenance treatment group. Meanwhile， 30 healthy volunteers were selected as the normal control group. The basal internal diameter of the brachial artery， the reactive hyperemic initial diameter of the brachial artery， the basal blood flow velocity of the brachial artery， the maximum blood flow velocity of the brachial artery after decompression， and the value of brachial artery blood flow-mediated internal diameter expansion were compared among the three groups. Result： The basal internal diameter of the brachial artery in the Methadone initial diagnosis group and the Methadone maintenance treatment group were significantly larger than those in the normal control group， and the Methadone initial diagnosis group was larger than the Methadone maintenance treatment group， the differences were statistically significant (P<0.05). The value of brachial artery blood flow-mediated internal diameter expansion in the Methadone initial diagnosis group and the Methadone maintenance treatment group was significantly lower than that in the normal control group， and the Methadone initial diagnosis group was lower than that in the Methadone maintenance treatment group， and the difference was statistically significant (P<0.05). The basal blood flow velocity of the brachial artery in the Methadone initial diagnosis group was significantly higher than that in the methadone maintenance treatment group and the normal control group， and the difference was statistically significant (P<0.05). There were no statistically significant differences among three groups in the the reactive hyperemic initial diameter of the brachial artery and the maximum blood flow velocity of the brachial artery after decompression (P>0.05). Conclusion： The blood flow-mediated vasodilation response technology can be used to follow up the vascular endothelial function of Methadone maintenance treatment patients for a long time， and the effect of Methadone maintenance treatment can be evaluated according to flow-mediated vasodilation response results， which is recommended to be widely used in clinical practice., 百拇医药(钟敏 彭云蓉 肖敏 罗燕萍 罗麟 范国裕 陆堃 黎明)
【关键词】 血流介导的血管舒张反应 美沙酮维持治疗 血管内皮功能 评估价值
doi：10.14033/j.cnki.cfmr.2020.12.011 文献标识码 B 文章编号 1674-6805(2020)12-00-03
Evaluation of Vascular Endothelial Function in Patients with Methadone Maintenance Treatment Using Blood Flow-mediated Vasodilation Response/ZHONG Min， PENG Yunrong， XIAO Min， LUO Yanping， LUO Lin， FAN Guoyu， LU Kun， LI Ming. //Chinese and Foreign Medical Research， 2020， 18(12)： -28
[Abstract] Objective： To evaluate the vascular endothelial function in patients with Methadone maintenance treatment by blood flow-mediated vasodilation. Method： A total of 52 drug abusers admitted in various medical institutions in this district from January 2017 to December 2018 were selected as the research objects. Among them， 24 cases with Methadone initial diagnosis were in the Methadone initial diagnosis group， and 28 cases with Methadone maintenance treatment were in the Methadone maintenance treatment group. Meanwhile， 30 healthy volunteers were selected as the normal control group. The basal internal diameter of the brachial artery， the reactive hyperemic initial diameter of the brachial artery， the basal blood flow velocity of the brachial artery， the maximum blood flow velocity of the brachial artery after decompression， and the value of brachial artery blood flow-mediated internal diameter expansion were compared among the three groups. Result： The basal internal diameter of the brachial artery in the Methadone initial diagnosis group and the Methadone maintenance treatment group were significantly larger than those in the normal control group， and the Methadone initial diagnosis group was larger than the Methadone maintenance treatment group， the differences were statistically significant (P<0.05). The value of brachial artery blood flow-mediated internal diameter expansion in the Methadone initial diagnosis group and the Methadone maintenance treatment group was significantly lower than that in the normal control group， and the Methadone initial diagnosis group was lower than that in the Methadone maintenance treatment group， and the difference was statistically significant (P<0.05). The basal blood flow velocity of the brachial artery in the Methadone initial diagnosis group was significantly higher than that in the methadone maintenance treatment group and the normal control group， and the difference was statistically significant (P<0.05). There were no statistically significant differences among three groups in the the reactive hyperemic initial diameter of the brachial artery and the maximum blood flow velocity of the brachial artery after decompression (P>0.05). Conclusion： The blood flow-mediated vasodilation response technology can be used to follow up the vascular endothelial function of Methadone maintenance treatment patients for a long time， and the effect of Methadone maintenance treatment can be evaluated according to flow-mediated vasodilation response results， which is recommended to be widely used in clinical practice., 百拇医药(钟敏 彭云蓉 肖敏 罗燕萍 罗麟 范国裕 陆堃 黎明)