脑小血管病MRI的表现与血管性认知功能障碍的相关性研究(1)
【摘要】 目的：研究脑小血管病(CSVD)磁共振成像(MRI)的表现与血管性认知功能障碍的相关性。方法：选取2017年6月-2020年2月笔者所在医院CSVD患者80例，其中血管性认知功能障碍(VCI)患者36例为VCI组，认知功能正常(NCI)患者44例为NCI组。两组均行MRI检查，比较表观弥散系数(ADC值)、脑白质变性(WML)发生率及蒙特尔认知评估量表(MoCA)与ADC值相关性。结果：VCI组左侧尾状核及丘脑ADC值均高于NCI组(P<0.05);VCI组WML发生率为58.33%，高于NCI组的31.82%(P<0.05);经Pearson相关性分析，CSVD患者MoCA评分与左侧丘脑ADC值呈负相关(r=-0.378，P<0.05)。结论：CSVD合并VCI患者的左侧尾状核及丘脑ADC值较高，可促进WML发生，且认知功能与左侧丘脑ADC值具有显著相关性。
【关键词】 脑小血管病 磁共振成像 血管性认知功能障碍 相关性
doi：10.14033/j.cnki.cfmr.2020.13.026 文献标识码 B 文章编号 1674-6805(2020)13-00-03
Study on the Correlation between MRI Findings and Vascular Cognitive Impairment in Cerebral Small Vessel Disease/LI Guoqin， GUO Chunmao， ZENG Zijuan. //Chinese and Foreign Medical Research， 2020， 18(13)： -66
[Abstract] Objective： To investigate the correlation between magnetic resonance imaging (MRI) findings and vascular cognitive impairment in cerebral small vessel disease (CSVD). Method： Eighty patients with CSVD in our hospital from June 2017 to February 2020 were selected， among whom 36 patients with vascular cognitive impairment (VCI) were in the VCI group and 44 patients with normal cognitive impairment (NCI) were in the NCI group. MRI was performed on both groups， and the apparent dispersion coefficient (ADC value)， the incidence of white matter lesions (WML) and the correlation between MoCA and ADC value were compared between the two groups. Result： The ADC values of left caudate nucleus and thalamus in the VCI group were higher than those of the NCI group (P<0.05). The incidence of WML in the VCI group was 58.33%， which was higher than 31.82% of the NCI group (P<0.05). According to Pearson correlation analysis， MoCA score of CSVD patients was negatively correlated with ADC value in the left thalamus (r=-0.378， P<0.05). Conclusion： The left caudate nucleus and thalamus of CSVD patients combined with VCI had higher ADC values， which promoted the occurrence of WML， and the cognitive function was significantly correlated with ADC values of left thalamic.
[Key words] Cerebral small vessel disease Magnetic resonance imaging Vascular cognitive impairment Correlation
First-author’s address： Huizhou Hospital of Traditional Chinese Medicine， Huizhou 516001， China
腦小血管病(CSVD)导致血管性认知功能障碍(VCI)占比高达70%，若干预不及时易发展为血管性痴呆，临床应早期诊断并延缓病情进展[1-2]。磁共振成像(MRI)中脑白质变性(WML)、腔隙性脑梗死(LI)、脑微出血(CMB)等均为CSVD的主要诊断指标，且与患者发生认知功能障碍具有一定关联性[3-4]。临床应及时判断患者病情并预防血管性痴呆形成。本研究选取笔者所在医院CSVD患者80例，旨在探讨CSVD的MRI表现与VCI的相关性，报道如下。, 百拇医药(李国勤 郭春茂 曾子娟)
【关键词】 脑小血管病 磁共振成像 血管性认知功能障碍 相关性
doi：10.14033/j.cnki.cfmr.2020.13.026 文献标识码 B 文章编号 1674-6805(2020)13-00-03
Study on the Correlation between MRI Findings and Vascular Cognitive Impairment in Cerebral Small Vessel Disease/LI Guoqin， GUO Chunmao， ZENG Zijuan. //Chinese and Foreign Medical Research， 2020， 18(13)： -66
[Abstract] Objective： To investigate the correlation between magnetic resonance imaging (MRI) findings and vascular cognitive impairment in cerebral small vessel disease (CSVD). Method： Eighty patients with CSVD in our hospital from June 2017 to February 2020 were selected， among whom 36 patients with vascular cognitive impairment (VCI) were in the VCI group and 44 patients with normal cognitive impairment (NCI) were in the NCI group. MRI was performed on both groups， and the apparent dispersion coefficient (ADC value)， the incidence of white matter lesions (WML) and the correlation between MoCA and ADC value were compared between the two groups. Result： The ADC values of left caudate nucleus and thalamus in the VCI group were higher than those of the NCI group (P<0.05). The incidence of WML in the VCI group was 58.33%， which was higher than 31.82% of the NCI group (P<0.05). According to Pearson correlation analysis， MoCA score of CSVD patients was negatively correlated with ADC value in the left thalamus (r=-0.378， P<0.05). Conclusion： The left caudate nucleus and thalamus of CSVD patients combined with VCI had higher ADC values， which promoted the occurrence of WML， and the cognitive function was significantly correlated with ADC values of left thalamic.
[Key words] Cerebral small vessel disease Magnetic resonance imaging Vascular cognitive impairment Correlation
First-author’s address： Huizhou Hospital of Traditional Chinese Medicine， Huizhou 516001， China
腦小血管病(CSVD)导致血管性认知功能障碍(VCI)占比高达70%，若干预不及时易发展为血管性痴呆，临床应早期诊断并延缓病情进展[1-2]。磁共振成像(MRI)中脑白质变性(WML)、腔隙性脑梗死(LI)、脑微出血(CMB)等均为CSVD的主要诊断指标，且与患者发生认知功能障碍具有一定关联性[3-4]。临床应及时判断患者病情并预防血管性痴呆形成。本研究选取笔者所在医院CSVD患者80例，旨在探讨CSVD的MRI表现与VCI的相关性，报道如下。, 百拇医药(李国勤 郭春茂 曾子娟)