开颅夹闭与介入栓塞在颅内动脉瘤中的效果及对机体应激的影响观察(1)
【摘要】 目的：观察开颅夹闭与介入栓塞在颅内动脉瘤中的效果及对机体应激的影响。方法：选取2017年1月-2018年12月的86例颅内动脉瘤患者为研究对象，根据治疗方式的不同将其分为A组(43例)和B组(43例)。A组采用开颅夹闭治疗，B组采用介入栓塞治療。比较两组术后GOS评分及机体应激指标(应激激素、炎性应激及氧化应激指标)。结果：观察组术后6个月GOS评分显著优于对照组，差异有统计学意义(P<0.05)。术前两组应激激素指标比较，差异无统计学意义(P>0.05);术后3、7 d B组应激激素指标均显著低于A组，差异有统计学意义(P<0.05)。术前两组炎性应激指标比较，差异无统计学意义(P>0.05);术后3、7 d B组炎性应激指标均显著低于A组，差异有统计学意义(P<0.05)。术前两组氧化应激指标比较，差异均无统计学意义(P>0.05);术后3、7 d B组SOD显著高于A组，MDA显著低于A组，差异均有统计学意义(P<0.05)。结论：介入栓塞在颅内动脉瘤中的效果优于开颅夹闭，且对机体应激的控制相对更好，因此在颅内动脉瘤患者中的应用价值较高。
【关键词】 开颅夹闭 介入栓塞 颅内动脉瘤 临床效果 机体应激
doi：10.14033/j.cnki.cfmr.2020.22.013 文献标识码 B 文章编号 1674-6805(2020)22-00-03
[Abstract] Objective： To observe the effect of craniotomy clipping and interventional embolization in intracranial aneurysm and its influence on body stress. Method： A total of 86 patients with intracranial aneurysm from January 2017 to December 2018 were selected as the study objects， and they were divided into group A(43 cases) and group B (43 cases) according to the different treatment methods. Postoperative GOS scores and body stress index (stress hormone， inflammatory stress and oxidative stress) were compared between the two groups. Result： The GOS score of the observation group 6 months after surgery was significantly better than that of the control group， and the difference was statistically significant (P<0.05). There were no significant differences in stress hormone index between the two groups before surgery (P>0.05). The stress hormone index of group B were significantly lower than those of group A at 3 and 7 days after surgery， and the differences were statistically significant (P<0.05). There were no significant differences in inflammatory stress index between the two groups before surgery (P>0.05). The inflammatory stress index of group B were significantly lower than those of group A at 3 and 7 days after surgery， and the differences were statistically significant (P<0.05). There were no significant differences in oxidative stress index between the two groups before surgery (P>0.05). The SOD in group B was significantly higher than that in group A， and MDA was significantly lower than that in group A at 3 and 7 days after surgery， the differences were statistically significant (P<0.05). Conclusion： The effect of interventional embolization in intracranial aneurysm is better than that of craniotomy clipping， and the control of body stress is relatively better， so the application value in patients with intracranial aneurysms is relatively high., http://www.100md.com(姜洪刚)
【关键词】 开颅夹闭 介入栓塞 颅内动脉瘤 临床效果 机体应激
doi：10.14033/j.cnki.cfmr.2020.22.013 文献标识码 B 文章编号 1674-6805(2020)22-00-03
[Abstract] Objective： To observe the effect of craniotomy clipping and interventional embolization in intracranial aneurysm and its influence on body stress. Method： A total of 86 patients with intracranial aneurysm from January 2017 to December 2018 were selected as the study objects， and they were divided into group A(43 cases) and group B (43 cases) according to the different treatment methods. Postoperative GOS scores and body stress index (stress hormone， inflammatory stress and oxidative stress) were compared between the two groups. Result： The GOS score of the observation group 6 months after surgery was significantly better than that of the control group， and the difference was statistically significant (P<0.05). There were no significant differences in stress hormone index between the two groups before surgery (P>0.05). The stress hormone index of group B were significantly lower than those of group A at 3 and 7 days after surgery， and the differences were statistically significant (P<0.05). There were no significant differences in inflammatory stress index between the two groups before surgery (P>0.05). The inflammatory stress index of group B were significantly lower than those of group A at 3 and 7 days after surgery， and the differences were statistically significant (P<0.05). There were no significant differences in oxidative stress index between the two groups before surgery (P>0.05). The SOD in group B was significantly higher than that in group A， and MDA was significantly lower than that in group A at 3 and 7 days after surgery， the differences were statistically significant (P<0.05). Conclusion： The effect of interventional embolization in intracranial aneurysm is better than that of craniotomy clipping， and the control of body stress is relatively better， so the application value in patients with intracranial aneurysms is relatively high., http://www.100md.com(姜洪刚)