儿童腺病毒肺炎的特点和重症肺炎的危险因素分析(1)
【摘要】 目的：探討儿童腺病毒(human adenovirus，HADV)肺炎的临床及实验室特点和重症肺炎的危险因素。方法：选择2019年7月1日-12月31日在中山大学附属第五医院儿科住院的32例腺病毒肺炎患儿的临床资料进行回顾性分析，分析患儿的临床及实验室特点和重症肺炎的危险因素。结果：32例腺病毒肺炎患儿中，1～3岁13例(40.6%)，15例(46.9%)合并1种以上的病原体感染，重症肺炎9例，占28.1%，非重症肺炎23例，占71.9%。单因素分析显示，重症肺炎患儿和非重症肺炎患儿年龄1～3岁占比、白细胞>10×109/L或<4×109/L占比、白蛋白水平比较，差异均有统计学意义(P<0.05);重症肺炎患儿和非重症肺炎患儿性别、结膜是否充血、是否合并肺炎支原体感染、是否合并1种及以上病原体感染、血红蛋白、血小板、降钙素原、C反应蛋白比较，差异均无统计学意义(P>0.05)。多因素Logistic分析结果显示，年龄1～3岁、白细胞>10×109/L或<4×109/L、白蛋白降低是引起重症肺炎发生的危险因素(P<0.05)。结论：年龄1～3岁、白细胞>10×109 /L或<4×109 /L、白蛋白降低的儿童腺病毒肺炎易发展为重症肺炎，对这些患儿应给予重点关注。
【关键词】 儿童肺炎 腺病毒感染 重症肺炎 危险因素
doi：10.14033/j.cnki.cfmr.2020.25.022 文献标识码 B 文章编号 1674-6805(2020)25-00-03
[Abstract] Objective： To investigate the clinical and laboratory characteristics of human adenovirus (HADV) pneumonia in children and risk factors for severe pneumonia. Method： The clinical data of 32 children with HADV pneumonia in the Fifth Affiliated Hospital of Sun Yat-sen University from July 1st to December 31st 2019 were retrospectively analyzed， and the clinical and laboratory characteristics in children， related factors of severe pneumonia were observed. Result： Among the 32 children with adenovirus pneumonia， 13 cases (40.6%) were 1-3 years old， 15 cases (46.9%) were infected with more than one pathogen， 9 cases (28.1%) had severe pneumonia， and 23 cases (71.9%) had non-severe pneumonia. Univariate analysis showed that there were statistically significant differences in the proportion of children with severe pneumonia and children with non-severe pneumonia aged 1-3 years， the proportion of white blood cells > 10×109/L or < 4×109/L， and the albumin level (P<0.05). There were no statistically significant differences in gender， conjunctival congestion， mycoplasma pneumoniae infection， infection with one or more pathogens， hemoglobin， platelets， procalcitonin and c-reactive protein between children with severe pneumonia and children with non-severe pneumonia (P>0.05). The multivariate logistic analysis showed that age from 1-3 years， leukocyte >10×109/L or <4×109/L， albumin reduction were risk factors for severe pneumonia (P<0.05). Conclusion： Adenovirus pneumonia in children aged 1-3 years old， leukocyte >10×109/L or <4×109/L， albumin reduction are likely to develop into severe pneumonia， and should be given special attention.
[Key words] Childhood pneumonia Human adenovirus infection Severe pneumonia Risk factors, 百拇医药(陈沫 寇丽 刘红兵)
【关键词】 儿童肺炎 腺病毒感染 重症肺炎 危险因素
doi：10.14033/j.cnki.cfmr.2020.25.022 文献标识码 B 文章编号 1674-6805(2020)25-00-03
[Abstract] Objective： To investigate the clinical and laboratory characteristics of human adenovirus (HADV) pneumonia in children and risk factors for severe pneumonia. Method： The clinical data of 32 children with HADV pneumonia in the Fifth Affiliated Hospital of Sun Yat-sen University from July 1st to December 31st 2019 were retrospectively analyzed， and the clinical and laboratory characteristics in children， related factors of severe pneumonia were observed. Result： Among the 32 children with adenovirus pneumonia， 13 cases (40.6%) were 1-3 years old， 15 cases (46.9%) were infected with more than one pathogen， 9 cases (28.1%) had severe pneumonia， and 23 cases (71.9%) had non-severe pneumonia. Univariate analysis showed that there were statistically significant differences in the proportion of children with severe pneumonia and children with non-severe pneumonia aged 1-3 years， the proportion of white blood cells > 10×109/L or < 4×109/L， and the albumin level (P<0.05). There were no statistically significant differences in gender， conjunctival congestion， mycoplasma pneumoniae infection， infection with one or more pathogens， hemoglobin， platelets， procalcitonin and c-reactive protein between children with severe pneumonia and children with non-severe pneumonia (P>0.05). The multivariate logistic analysis showed that age from 1-3 years， leukocyte >10×109/L or <4×109/L， albumin reduction were risk factors for severe pneumonia (P<0.05). Conclusion： Adenovirus pneumonia in children aged 1-3 years old， leukocyte >10×109/L or <4×109/L， albumin reduction are likely to develop into severe pneumonia， and should be given special attention.
[Key words] Childhood pneumonia Human adenovirus infection Severe pneumonia Risk factors, 百拇医药(陈沫 寇丽 刘红兵)