新生儿乙肝疫苗免疫无应答的影响因素(1)
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【摘要】目的：探讨新生儿乙肝疫苗免疫无应答的影响因素，为临床上注射乙肝疫苗提供依据。方法 对2010年10月-2011年12月在本院进行乙肝疫苗接种的825例新生儿，采用化学发光微粒子免疫分析法对新生儿的乙肝病毒表面抗体进行检测，同时对家长进行调查，分析新生儿出生状况。结果 男性患者无应答率为1.24%，女性患者无应答率为1.65%，女性患者无应答率高于男性患者，但两组间差异不具有统计学意义(P>0.05)；7-12月龄患者无应答率为0.25%，13-18月龄患者无应答率为4.03%，13-18月龄患者无应答率高于7-12月龄的患者，两组间差异具有统计学意义(P<0.05)；低体重患者无应答率为4.66%，正常体重和超重患者无应答率分别为1.91%和0.72%，低体重患者无应答率高于正常体重及超重患者，组间差异具有统计学意义(P<0.05)；早产儿患者的无应答率高于足月儿患者，两组间差异具有统计学意义(P<0.05)。结论 新生儿的月龄、是否早产、母体孕期乙肝表面抗原情况等因素对于新生儿乙肝疫苗免疫应答情况具有很大的影响，对早产儿等免疫无应答高危新生儿应进行乙肝抗体监测。
【关键词】新生儿，乙肝疫苗，免疫无应答，影响因素；
Neonatal hepatitis B vaccine immune unresponsiveness of the influencing factors
Cai Pingan( The Centers for Disease Control of Suining Anju district,suining,Sichuan Suining 629006 )
[Abstract]: Objective: To investigate the neonatal hepatitis B vaccine immune unresponsiveness of influencing factors, clinical hepatitis B vaccine injection provide a basis. Methods from 2010 October -2011 year in December at the Institute for hepatitis B vaccination in 825 Cases of neonatal, by chemiluminescent microparticle immunoassay on neonatal hepatitis B virus surface antibody for detection, while the parents were investigated, analysis of the neonatal birth status. Results the male patients without a response rate of 1.24%, a female patient without a response rate of 1.65%, a female patient without the response rate is higher than male patients, but the difference between the two groups was not statistically significant ( P>0.05 ); 7-12 months in patients without a response rate of 0 ......
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