摘要：阿尔茨海默病(Alzheimer’s disease, AD)是老年痴呆中最常见的类型，并以记忆和其他高级认知功能进行性减退为特征的神经退行性疾病。近年来，研究提出AD时一种失连接综合症，即AD患者不仅在局部脑区存在结构和功能的异常，在脑区之间的功能连接也存在异常。本文主要回顾近年来基于种子点功能连接研究在MCI和AD中的进展，这些发现不仅为了解其病理生理学机制提供了新的视角，也为疾病的早期诊断寻找到敏感的影像学标记。

    关键词: 阿尔茨海默病；轻度认知障碍；功能连接；功能磁共振成像

    Disrupted resting-state functional connectivity in mild cognitive impairment and Alzheimer’s disease

    Abstract: Alzheimer’s disease (AD) is the most frequent type of dementia, including an estimated 60%-80% of all dementia cases. It can be clinically characterized by impairments of memory and other high cognitive functions. Previous studies suggested that these impairments are not only associated with disrupted of brain regions structure and function but with abnormal functional connections among brain regions, leading to a disconnection notion in AD. In this review, we summarize the recent progress of seed-based functional connectivity studies in AD and mild cognitive impairment (MCI ......