摘 要：自噬是将细胞内受损、变性或衰老的蛋白质以及细胞器运输到溶酶体进行消化降解的过程.正常生理情况下，细胞自噬利于细胞保持自稳状态；在发生应激时，细胞自噬防止有毒或致癌的损伤蛋白质和细胞器的累积，抑制细胞癌变；然而肿瘤一旦形成，细胞自噬为癌细胞提供更丰富的营养，促进肿瘤生长.因此，在肿瘤发生发展的过程中，细胞自噬的作用具有两面性.对于细胞自噬和肿瘤发生之间的关系有待深入的研究，这将会有助于人类更好地认识并最终攻克肿瘤。

    关键词：肿瘤，自噬，抗肿瘤药物

    Abstract： Autophagy is the major intracellular degradation system by which cytoplasmic materials (denatured protein， damaged organelles) are delivered to and degraded in the lysosome to maintain homeostasis. Once carcinogenesis rising up， autophagy would be also employed by cancer cells. Autophagy plays an important role in cancer cells– both in protecting against cancer as well as potentially contributing to the growth of cancer. However ......