补肾活血汤治疗膝骨关节炎(肾虚血瘀证)的临床研究(1)
摘要： 目的： 观察补肾活血汤治疗膝关节骨性关节炎(肾虚血瘀证)的临床疗效和安全性。方法： 将膝骨关节炎患者80例随机分为补肾活血汤组(观察组)40例与硫酸氨基葡萄糖组(对照组)进行比较研究。观察患者治疗前后临床症状的改善、W0MAC和中医肾虚血瘀证候评分及关节液中炎症因子水平的变化。结果： (1)观察组临床疗效优于对照组(P<0.05)；(2)两组治疗后疼痛、功能、总W0MAC等积分均较治疗前降低(P<0.05)，且观察组改善优于对照组(P<0.05)；(3)两组治疗后肾虚、血瘀、舌脉、总评分均较治疗前降低(P<0.05)，且观察组改善优于对照组(P<0.05)。(4)两组治疗后肿瘤坏死因子-α(TNF-a)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)含量均较治疗前降低(P<0.05)；白细胞介素-10(IL-10)均较治疗前升高(P<0.05)，两组比较差异无统计学意义(P >0.05)。(5)在治疗过程中，观察组无严重不良反应发生。结论：补肾活血汤治疗膝骨关节炎安全、有效。
关键词：膝骨关节炎；肾虚血瘀；补肾活血汤；肿瘤坏死因子-α；白细胞介素-1β；白细胞介素-8；白细胞介素-10
, 百拇医药
Abstrac： Objective； The clinical efficacy.and safty Of BuShen HuoXue Soup in the treatment of knee osteoarthritis(syndrome of kidney essence deficiency) was observed.Methods： 80 patients with knee osteoarthritis were randomly divided into 40cases of BuShen HuoXue Soup group(observation group) and 40 cases of glucosamine sulfate(control group). The changes before and after treatment in patients with clinical symptoms， W0MAC and TCM Syndrome Kidney Blood score，Tumor necrosis factor-a，interleukin-1β，interleukin-8，interleukin -10 level were.observed.Results： (1) the clinical curative effect of the observation group was better than the control group (P<0.05).(2) The ？score of pain，function，W0MAC，etc.have been decreased than before？(P<0.05)，？the improvement in observation group was better than control (P<0.05).(3) The kidney deficiency，？blood stasis，？tongue and pulse，？total？scores have been decreased than before？(P<0.05)， the improvement in observation group was better than control (P<0.05).(4) Tumor necrosis factor-a(TNF-a)，interleukin-1β(IL-1β)，interleukin-8(IL-8)in two groups decreased after treatment (P<0.05)，interleukin-10(IL-10)content of two groups increased (P<0.05)，but no statistical differences(P>0.05).(5) No serious adverse reactions were observed in the observation group during treatment. Conclusion： BuShen HuoXue Soup is safe and effective in treating knee osteoarthritis.
, 百拇医药
Keywords： knee osteoarthritis；Kidney deficiency and blood stasis；BuShen HuoXue Soup；TNF-a；IL-1β；IL-8；IL-10
膝骨关节炎(osteoarthritis OA)是一种骨伤科常见退变性疾病。研究表明：人群膝骨关节炎患病率达 9.56%， 老年人群则明显增高达 50%以上[1]。由于膝关节为人体负重关节，且易受外力损伤，故膝骨关节炎在四肢中发病率最高。其早期表现为髌股骨关节炎，中期、晚期表现为关节间隙变窄、消失，软骨破坏伴畸形。我们自2011年6月～2013年6月采用补肾活血汤治疗膝关节骨性关节炎肾虚血瘀证取得良好疗效，现总结报告如下。
1 资料与方法
1.1 一般资料
所观察病例80例患者均为湖南中医药大学第一附属医院门诊及住院患者。其中住院患者42例，门诊患者38例。随机分为观察组40例， 对照组40例。其中观察组男17例，女23例，单侧26例，双侧14例；Ⅱ级21例，Ⅲ级19例，年龄(51.33±2.22)岁，病程(2.34±1.22)月；对照组男19例，女21例，单侧27例，双侧13例，Ⅱ级22例，Ⅲ级18例，年龄(50.24±1.83)岁，病程(2.25±1.17)月。两组病例性别、年龄、病程、X线分级、病情评分、关节液炎症因子水平等方面，差异无统计学意义( P>0.05)，具有可比性。, 百拇医药(罗振华 郭彦涛 杨少锋 邓博 聂颖)
关键词：膝骨关节炎；肾虚血瘀；补肾活血汤；肿瘤坏死因子-α；白细胞介素-1β；白细胞介素-8；白细胞介素-10
, 百拇医药
Abstrac： Objective； The clinical efficacy.and safty Of BuShen HuoXue Soup in the treatment of knee osteoarthritis(syndrome of kidney essence deficiency) was observed.Methods： 80 patients with knee osteoarthritis were randomly divided into 40cases of BuShen HuoXue Soup group(observation group) and 40 cases of glucosamine sulfate(control group). The changes before and after treatment in patients with clinical symptoms， W0MAC and TCM Syndrome Kidney Blood score，Tumor necrosis factor-a，interleukin-1β，interleukin-8，interleukin -10 level were.observed.Results： (1) the clinical curative effect of the observation group was better than the control group (P<0.05).(2) The ？score of pain，function，W0MAC，etc.have been decreased than before？(P<0.05)，？the improvement in observation group was better than control (P<0.05).(3) The kidney deficiency，？blood stasis，？tongue and pulse，？total？scores have been decreased than before？(P<0.05)， the improvement in observation group was better than control (P<0.05).(4) Tumor necrosis factor-a(TNF-a)，interleukin-1β(IL-1β)，interleukin-8(IL-8)in two groups decreased after treatment (P<0.05)，interleukin-10(IL-10)content of two groups increased (P<0.05)，but no statistical differences(P>0.05).(5) No serious adverse reactions were observed in the observation group during treatment. Conclusion： BuShen HuoXue Soup is safe and effective in treating knee osteoarthritis.
, 百拇医药
Keywords： knee osteoarthritis；Kidney deficiency and blood stasis；BuShen HuoXue Soup；TNF-a；IL-1β；IL-8；IL-10
膝骨关节炎(osteoarthritis OA)是一种骨伤科常见退变性疾病。研究表明：人群膝骨关节炎患病率达 9.56%， 老年人群则明显增高达 50%以上[1]。由于膝关节为人体负重关节，且易受外力损伤，故膝骨关节炎在四肢中发病率最高。其早期表现为髌股骨关节炎，中期、晚期表现为关节间隙变窄、消失，软骨破坏伴畸形。我们自2011年6月～2013年6月采用补肾活血汤治疗膝关节骨性关节炎肾虚血瘀证取得良好疗效，现总结报告如下。
1 资料与方法
1.1 一般资料
所观察病例80例患者均为湖南中医药大学第一附属医院门诊及住院患者。其中住院患者42例，门诊患者38例。随机分为观察组40例， 对照组40例。其中观察组男17例，女23例，单侧26例，双侧14例；Ⅱ级21例，Ⅲ级19例，年龄(51.33±2.22)岁，病程(2.34±1.22)月；对照组男19例，女21例，单侧27例，双侧13例，Ⅱ级22例，Ⅲ级18例，年龄(50.24±1.83)岁，病程(2.25±1.17)月。两组病例性别、年龄、病程、X线分级、病情评分、关节液炎症因子水平等方面，差异无统计学意义( P>0.05)，具有可比性。, 百拇医药(罗振华 郭彦涛 杨少锋 邓博 聂颖)