抗菌药物用量与细菌耐药性的相关性分析
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摘 要:目的 :探讨抗菌药物用量与细菌耐药性之间的关系,为控制感染提供依据。方法: 对2008~2010年常用抗菌药物的使用频率及常见细菌耐药性进行分析。结果: 三年以来常用抗菌药物的DDDs由6042上升到8111,增长了34.24%,其中头孢哌酮他唑巴坦、头孢呋辛和头孢西丁用量增长明显。致病菌以革兰氏阴性菌为主,在11种常用抗菌药物中,氨苄西林舒巴坦对四种病原菌的耐药率均比较高;哌拉西林钠他唑巴坦钠、头孢哌酮他唑巴坦和亚胺培南西司他丁的敏感率较高,阿莫西林克拉维酸钾对非产ESBLs的大肠埃希菌较敏感,鲍曼不动杆菌对其他药物的耐药率较高。结论: 细菌耐药性与抗菌药物的使用频度增加存在一定相关性,应加强细菌耐药性监测与合理用药指导。
关键词:抗菌药物;DDD值;DDDs;耐药性
Abstract:Objective to investigate the antibacterial drug dosage and the relationship between the bacterial drug resistance, provide the basis for infection control. Methods from 2008 to 2010 commonly used antimicrobial drug use frequency and common bacteria resistance were analyzed. Results three years commonly used the DDDs of antibiotics from 6042 to 8111, increased by 34.24%, with cefoperazone he azole temple, cefuroxime, and amount of cefoxitin growth significantly. Pathogenic bacteria is given priority to with gram-negative bacteria ......
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