【摘要】目的:比较常规皮下注射胰岛素(MSII)与胰岛素泵(CSII)治疗2型糖尿病疗效及安全性的差别。方法: 采用对照研究方法比较常规皮下注射胰岛素与胰岛素泵两种治疗方法在控制血糖、胰岛素剂量、低血糖发生率上的差别。结果: 胰岛素泵治疗组达到理想血糖控制疗效所需时间明显优于常规皮下注射组(P<0.01)；胰岛素泵治疗组达到理想血糖控制疗效所需胰岛素剂量明显少于常规皮下注射组(P<0.05)；胰岛素泵治疗组低血糖发生率低于常规皮下注射组(P<0.01)。结论: 胰岛素泵治疗能够缩短达到理想血糖控制所需时间，有效降低餐后2小时血糖，减少胰岛素用量，减少低血糖的发生。

    【关键词】糖尿病 胰岛素泵 连续皮下胰岛素注射 多次皮下胰岛素注射

    Clinical study of insulin pumps in 827 diabetic patients

    Lou Jianhua Zhen Guangxia Li Donghai

    【Abstract】AIM: To compare the differences of the therapeutic effect and safety of continuous subcutaneous insulin infusion by insulin pump (CSII) and multiple subcutaneous insulin infusion (MSII) in treatment of type 2 diabetic patients. METHODS: The differences of controlling blood glucose insulin dosage and hypoglycemic episodes both in CSII group with insulin pump and MSII group are compared by a match study. RESULTS: The time needed for reaching well controlled blood glucose levels in CSII group was significantly shorter than that of patients in MSII group (P<0.01); the insulin dosage needed for reaching well controlled blood glucose level in CSII group was obviously less than that of the MSII group (P<0.01)； hypoglycemia episodes of CSII group was also lower than that of MSII group (P<0.01). CONCLUSION: As a new efficacious therapy for type 2 diabetic patients, CSII can shorten the duration of insulin treatment, reduce insulin dosage and hypoglycemic episodes and is more safe and effective than MSII. ......