摘 要目的：观察氨甲蝶呤(MTX)联合米非司酮保守治疗异位妊娠临床疗效。方法：观察组84例:MTX0·4mg/kg,肌肉注射,1天1次,连用5天,米非司酮50mg/次,口服,1天2次,连服6天；对照组65例:MTX0·4mg/kg,肌肉注射,1天1次,连用5天。治疗期间严密观察腹疼、阴道流血和生命体征改变。结果在阴道流血和血β-HCG降至正常时间、异位妊娠包块吸收时间上,观察组均明显优于对照组(P<0·05)。结论：氨甲喋呤联合米非司酮治疗异位妊娠有较好疗效。

    关键词输卵管妊娠；氨甲蝶呤；米非司酮

    AbstractObjective：To investigate the efficacy of methotrexate(MTX) in combination with mifepfistone in the conservative treatment of nonrupture ectopic pregnancy.Methods：121 patients with nonrupture ectopic pregnancy were enrolled in the study.Patients were further divided into two groups according to whether mifepristone was used: mifepristone 50mg twice daily for 6 days(Group A)or without it (Group B).MTX dose was the same in both groups: 0·4mg/kg for 5 days. Vital signs,serumβ-HCG levels and tranvaginaonly ultrasonography were monitored.ResultsGroup A had a higher success rate in the cure rate of ectopic pregnancy,the time of serumβ-HCG levels decreased to normal.ConclusionMTX in combination with mifepfistonein in the conservative treatment of nonrupture ectopic pregnancy can be established universal treatment guidelines. ......