摘 要目的:研究丹参川穹嗪注射液对冠心病易损斑块的稳定作用。方法:选择冠心病易损斑块患者60例,随机分为丹参川穹嗪注射液治疗组(30例)和常规治疗组(30例),比较2组治疗前后血清纤维蛋白原(Fg)及超敏C反应蛋白 (Hs-CRP)水平的变化及发生心脏事件的数量。结果:丹参川穹嗪治疗组比常规治疗组治疗后血清纤维蛋白原及Hs-CRP水平下降更明显,心脏事件减少,差异有统计学意义。结论:丹参川穹嗪注射液可降低冠心病易损斑块患者血清Fg及sCRP水平,稳定动脉粥样硬化斑块,减少心脏事件的发生。冠状动脉易损斑块患者在常规治疗的基础上联合应用丹参川穹嗪注射液获益更大。

    关键词丹参川穹嗪注射液;冠脉螺旋CT;易损斑块;纤维蛋白原;超敏C反应蛋白

    AbstractObjective: To research the stabilizing effect of Chuan Qiong Danshen injection triazine to vulnerable plaque of coronary heart disease (CHD) patients. Methods: A total of 60 CHD patients with vulnerable plaques were selected and divided into two groups at random: One is Chuan Qiong Danshen injection triazine treatment group(30 patients),the other is conventional treatment group(30 patients). Compare the change of the fibrinogen (Fg) and the high-sensitivity C-reactive protein (Hs-CRP) in the serum of the two group patients, as well as the number of cardiac events before and after treatments. Results: The serum levels of the Fg and the Hs-CRP in the Chuan Qiong Danshen injection triazine treatment group were more significantly declined than the conventional treatment group. And the incidence of the cardiac events was also significantly reduced in the Chuan Qiong Danshen injection triazine treatment group. The difference was statistically significant. Conclusions: The Chuan Qiong Danshen injection triazine can reduce the serum levels of the Fg and the Hs-CRP in coronary heart disease patients with vulnerable plaques, stabilize the atherosclerotic plaques, and reduce the incidence of the cardiac events. The coronary heart disease patients with vulnerable plaques will receive greater benefits at conventional treatments combined with Chuan Qiong Danshen injection triazine treatments. ......