摘 要目的:观察咪达唑仑联合芬太尼在重症监护病房(ICU)COPD患者有创机械通气中的应用,评价其镇静效果及安全性。方法:93例有创机械通气的COPD患者,给予咪达唑仑联合芬太尼持续静脉泵入,观察镇静效果,定时观察意识状态,人机协调,呼吸动力学指标及动脉血气分析。结果:给予咪达唑仑联合芬太尼后, 94.6%(88/93)的患者Ramsay评分达2分～4分,用药后患者呼吸动力学指标(PIP、PP、PM、RI、RE、CMP)及SpO2、pH、PCO2、PO2均有明显改善,有统计学意义(P<0. 05)。结论:咪达唑仑联合芬太尼在COPD患者机械通气时镇静效果好,安全性高。

    关键词咪达唑仑;机械通气;COPD

    AbstractObjective: To observe the combined midazolam fentanyl in the intensive care unit (ICU) COPD patients with invasive mechanical ventilation in the application, to evaluate its efficacy and safety of sedation. Methods: 93 cases of invasive mechanical ventilation in COPD patients given midazolam combined continuous intravenous infusion of fentanyl was observed sedative effect, from time to time to observe state of consciousness, human-machine coordination, respiratory parameters and arterial blood gas analysis. Results: midazolam given joint after fentanyl, 94.6% (88/93) of patients with Ramsay score of 2 to 4 hours after administration in patients with respiratory parameters (PIP, PP, PM, RI, RE, CMP) and SpO2, pH, PCO2, PO2 were significantly improved, with statistical significance (P <0. 05). Conclusion: The combined midazolam fentanyl in patients with COPD when the sedative effects of mechanical ventilation, and safety. ......